African Journal of
Food Science

  • Abbreviation: Afr. J. Food Sci.
  • Language: English
  • ISSN: 1996-0794
  • DOI: 10.5897/AJFS
  • Start Year: 2007
  • Published Articles: 837

Full Length Research Paper

Accumulation and clearance of orally administered erythromycin in adult Nile tilapia (Oreochromis niloticus)

Minh Nguyen Phuoc1,2*, Lam Tran Bich1,2, Giao Nguyen Trong3,4 and Quan Ngo Chinh3,4
1University of Technology, VNU-HCM, VN, Vietnam. 2268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam. 3Vietnam - Russia Tropical Center, South Branch, VN, Vietnam. 43 3/2 Street, District 10, HCM City, Vietnam.
Email: [email protected]

  •  Accepted: 16 August 2010
  •  Published: 30 September 2010


Nile tilapia (Oreochromis niloticus) were medicated with erythromycin base via the medicated ration at 50 and 100 mg erythromycin·kg-1 fish body weightday-1 for 7 days. Erythromycin residues in their muscle were determined by LC-MS/MS method through TUV Rheinland Aimex Vietnam Co., Ltd.  The results predicted withdrawal time for Nile tilapia was 33 days (908°C-day) if treated by the former dose or 42 days (1150°C-day) if treated by the later dose under our experimental conditions. Derivative biotransformation of erythromycin such as erythromycin C, E, F appeared in post-dosing stage, all of them were depleted to safe level if we strictly followed the withdrawal time and chemotherapeutic dosage as recommendation.


Key words: Erythromycin, tilapia; withdrawal time, LC-MS/MS, biotransformation.