Abstract

Cytomegalovirus is one of the most common microorganisms that cause opportunistic infection that complicate the clinical care and progress of immunecompromised patients. The virus can cause severe diseases with multiple complications including type I diabetes mellitus. The present study is a case control study aimed at determining cytomegalovirus among type I diabetic mellitus in Sudanese children. Sera of eighty one (81) children were collected, 27 (33.3%) from diabetic which represent the study group and 54 (66.7%) from apparently healthy children (control group). The samples were tested for IgG anti-cytomegalovirus using enzyme-linked immunosorbent assay (ELISA) technique. 18 (22.2%) of the total population of study were sero-positive for cytomegalovirus IgG, most of them, 10 (55.6%) were diabetic patients, the results indicate significant association (P value 0.025) of cytomegalovirus IgG antibodies with type I diabetes mellitus in children. The study reveals significant relation (P value 0.003) of cytomegalovirus IgG antibodies with type I diabetes mellitus in age group (5-9 years).

Key words: Cytomegalovirus, type I diabetes mellitus, children.