African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Genetic variation analysis of hemagglutinin and neuraminidase of human influenza A/H3N2 virus in Hong Kong (1997-2006)

Shubo Zhang
  • Shubo Zhang
  • School of Life Sciences, Sun Yat-sen University, China
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Jake Yue Chen
  • Jake Yue Chen
  • 2. School of Informatics, Indiana University, USA; 3. Department of Computer and Information Science, School of Science, Purdue University, USA. 4. Indiana Center for Systems Biology and Personalized Medicine, USA
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Jianan Rao
  • Jianan Rao
  • School of Life Sciences, Sun Yat-sen University, China
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Shanghong Zhang
  • Shanghong Zhang
  • School of Life Sciences, Sun Yat-sen University, China
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Daniel Wai Tin Chan
  • Daniel Wai Tin Chan
  • Research Centre of Built Environment and Energy Conservation, Institute for Advanced Study, Nanchang University, China
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Guanghua Liu
  • Guanghua Liu
  • Guangdong AIB Polytechnic College, China
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Yang Xu
  • Yang Xu
  • Department of Biotechnology, Southern Medical University, China
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Miao He*
  • Miao He*
  • School of Life Sciences, Sun Yat-sen University, China
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  •  Received: 17 May 2012
  •  Accepted: 07 April 2014
  •  Published: 30 April 2014

Abstract

We analyzed the phylogeny, amino acid variations, positive selection, and glycosylation patterns of hemagglutinin (HA) and neuraminidase (NA) of A/H3N2 in Hong Kong from 1997 to 2006. The results suggest that continuity and latency of influenza viruses might be the reasons why different influenza viruses co-circulate within the same season. Many amino acid mutations were retained for two or more successive years. The preferred antigenic sites of mutation are sites A and B in HAs, and site B in NAs. An influenza pandemic may be caused by higher-than-threshold level of amino acid variations of the virus.

Key words: Influenza virus, A/H3N2, phylogenetic analysis, selection pressure, N-glycosylation.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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