Abstract

Samples of 262 high vaginal swabs collected from patients attending Ogun State College of Health Technology, Ilese-Ijebu were screened for sexually transmitted diseases (STDs) pathogen and antimicrobial susceptibility pattern. Micro-organisms isolated from these samples include; Niesseria gonorrhea, Staphylococcus aureus, Gardnerella vaginalis, Candida albican and Escherichia coli. Age group 21 to 25 had the highest occurrence of pathogens. About 81.8% of the pathogens isolated showed resistance to five or more antibiotics while 6.81% showed resistance to one antibiotic. S. aureus was found to be the most sensitive when tested against Ofloxacine and Nitrofuratoin with 25 mm zone of inhibition. G. vaginalis had minimum inhibitory concentration (MIC) ranging from 32 to 128 µg/ml while N. gonorrhea had MIC ranging from 16 to 512 µg/ml when tested against tetracycline, ampiclause, ampicilline, gentamycin and augmentin. G. vaginalis had minimum bactericidal concentration (MBC) ranging from 32 to 128 µglml for tetracycline, nitrofuratoin, ampicilline, ampiclause and metronidazole while N. gonorrhea had MBC of 32 µg/ml for tetracycline and 512 µg/ml for ampicilline, ampiclause and gentamycin. Since micro-organisms continue to develop resistant to antibiotics, constant antimicrobial surveillance required to provide safety and effective therapy.

Key words: Antibiotics, STD pathogens, multi-drug resistance, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).