African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Cause and effect of Plumbago zeylanica root extract on blood glucose and hepatic enzymes in experimental diabetic rats

Muftah M. Zarmouh1, Karthikeyan Subramaniyam1*, Viswanathan S.2 and Kumar PG2  
1Faculty of Medicine, Misurata University, Misurata, Libya. 2PG, Department of Microbiology, Sri Paramakalyani College, India.  
Email: [email protected]

  •  Accepted: 11 November 2010
  •  Published: 18 December 2010

Abstract

 

This paper reports the results of oral administration of root extract of Plumbago zeylanica on blood glucose and plasma antioxidant status in streptozotocin (STZ) diabetic rats. The study was undertaken to evaluate hepatic enzymes in experimental diabetes. Oral administration of ethanolic extract (100, 200 mg/kg) in streptozotocin diabetic rats increased hepatic hexokinase activity and decreased hepatic glucose-6-phosphatase, serum acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The Plumbago zeylanica root extract is hypoglycemic, hepatoprotective and is able to ameliorate biochemical damages in Streptozotocin induced diabetic rats.

 

Key words: Plumbago zeylanica, STZ diabetes, hepatic enzymes, liver protection.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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