African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Variables determining the virologic response to adefovir treatment in patients with chronic HBV infection previously treated with lamivudine

Ceylan Bahadir1*, Fincanci Muzaffer2, Muderrisoglu Cuneyt3, Soysal Ferda2, Eren Gulhan2, and Metin Basaranoglu4
1Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey. 2Department of Infectious Diseases and Clinical Microbiology, Istanbul Training and Research Hospital, Istanbul, Turkey. 3Department of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey. 4Department of Gastroenterology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Email: [email protected]

  •  Accepted: 27 November 2012
  •  Published: 01 January 2013

Abstract

The objective of this study was the investigation of the variables that determine the development of virological response to adefovir treatment. In this retrospective case-control study, files of patients with chronic HBV infection which previously used adefovir throughout  different periods were examined for gender, age, height, weight, Knodell and fibrosis scores in liver biopsies, serum  ALT and HBV DNA levels, HBeAg status and alcohol use. Independent variables determining the virologic response to adefovir treatment were investigated. This study included 63 patients. Forty-one (65.1%) of the patients were male, and their median ages were 42 (range 19 to 65). Twenty-five (39.7%) of the study population were HBeAg positive. The cumulative virological response rates on the 6th, 12th, 18th, 24th, 30th and 36th months of adefovir therapy were found to be 31.7, 38.4, 38.4, 44, 44 and 58%, respectively. HBeAg negativity and the ratio of decrease in serum HBV DNA levels at 6th month of the treatment were the independent variables determining the response to the adefovir treatment [Odds ratio (95% confidence intervals) were 4.498 (1.194-16.939) for HBeAg negativity (p=0,026) and 1.598 (1.232-2.072) for the ratio of decrease in serum HBV DNA levels at 6th month of the treatment (p=0.0001). It was suggested that adefovir was more effective in HBeAg negative patients, and was more rational to continue the treatment in patients who had a decrease of at least 2log10units in serum HBV DNA levels at 6th month of treatment.

 

Key words: Adefovir, virologic response, HBV.