African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Transcript abundance of bovine NRAMP1 and iNOS genes among Brucella sero-reactive cattle and buffalo

Sanjeev Ranjan*
  • Sanjeev Ranjan*
  • Division of Animal Genetics, IVRI, Izatnagar, Bareilly, U.P-243122, India
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Arjava Sharma
  • Arjava Sharma
  • Division of Animal Genetics, IVRI, Izatnagar, Bareilly, U.P-243122, India
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Ashish Chopra
  • Ashish Chopra
  • Division of Animal Genetics, IVRI, Izatnagar, Bareilly, U.P-243122, India
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Abhijit Mitra
  • Abhijit Mitra
  • Division of Animal Genetics, IVRI, Izatnagar, Bareilly, U.P-243122, India
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  •  Received: 11 January 2014
  •  Accepted: 22 April 2014
  •  Published: 30 April 2014

Abstract

Brucella abortus and Brucella melitensis are the causative agents associated with brucellosis among cattle and buffaloes, respectively. NRAMP1 and iNOS are the best characterized genes conferring resistance against several intracellular organisms. The present study was undertaken to analyze transcript abundance of NRAMP1 and iNOS genes among Brucella sero-reactive cattle and buffalo. Our studies revealed that seropositive animals have significantly (P<0.05) higher mRNA transcript expression of both genes as compared to seronegative animals. Therefore, the present study shows that both NRAMP1 and iNOS genes are important candidates for the host response to Brucella among cattle and buffalo.

Key words: Bovine brucellosis, NRAMP1, iNOS.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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