African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Enhanced immune responses in mice to combined immunization with Mycobacterium tuberculosis Ag85A and DDA/MPL

Dan Zhao
  • Dan Zhao
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Weijun Tan
  • Weijun Tan
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Zhengzhong Xu
  • Zhengzhong Xu
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Xiang Chen
  • Xiang Chen
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Shuyang Ye
  • Shuyang Ye
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Kai Lian
  • Kai Lian
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Zhiming Pan
  • Zhiming Pan
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Yuelan Yin*
  • Yuelan Yin*
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar
Xinan Jiao*
  • Xinan Jiao*
  • Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Jiangsu Province, Yangzhou University, Yangzhou 225009, Jiangsu, China
  • Google Scholar


  •  Received: 28 March 2014
  •  Accepted: 13 June 2014
  •  Published: 02 July 2014

References

Armitige LY, Jagannath C, Wanger AR, Norris SJ (2000). Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages. Infect immun. 68(2):767-778.
Crossref
 
Betts G, Poyntz H, Stylianou E, Reye-Sandoval A, Cottingham M, Hill A, McShane H (2012). Optimising immunogenicity with viral vectors: mixing MVA and HAdV-5 expressing the mycobacterial antigen Ag85A in a single injection. PLoS One 7(12): e50447.
Crossref
 
Borremans M, de Wit L, Volckaert G, Ooms J, de Brujn J, Huygen K, van Vorren J, Stelandre M, Verhofstadt R, Content J (1989). Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis. Infect immun. 57(10):3123-3130.
Pubmed
 
Brandt L, Elhay M, Rosenkrands I, Lindblad EB, Andersen P (2000). ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect immun. 68(2):791-795.
Crossref
 
Dai J, Pei D, Wang B, Kuang Y, Ren L, Cao K, Zuo B, Shao J, Li S, Jiang Z, Li H, Li M (2013). A novel DNA vaccine expressing the Ag85A-HA2 fusion protein provides protection against influenza A virus and Staphylococcus aureus. Virol. J. 10:40.
Crossref
 
Dai J, Pei D, Wang BN. Kuang Y, Ren L, Cao K, Wang H, Zuo B, Shao J, Li S, Li H, Li M (2012). Molecular adjuvant Ag85A enhances protection against influenza A virus in mice following DNA vaccination. Viruses 4(12): 3606-3624.
Crossref
 
Fan X, Gao Q, Fu R (2009). Differential immunogenicity and protective efficacy of DNA vaccines expressing proteins of Mycobacterium tuberculosis in a mouse model. Microbiol. Res. 164(4): 374-382.
Crossref
 
Hu S, Chen H, Ma J, Chen Q, Denq H, Gong F, Huang H, Shi C (2013). CpG7909 adjuvant enhanced immunogenicity efficacy in mice immunized with ESAT6-Ag85A fusion protein, but does not confer significant protection against Mycobacterium tuberculosis infection. J. Appl. Microbiol. 115(5):1203-1211.
Crossref
 
Kaufmann SH (2005). Recent findings in immunology give tuberculosis vaccines a new boost. Trends Immunol. 26(12): 660-667.
Crossref
 
Korsholm KS, Agger EM, Foged C, Christensen D, Dietrich J, Andersen CS, Geisler C, Andersen P (2007). The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes. Immunology 121(2):216-226.
Crossref
 
Korsholm KS, Petersen RV, Agger EM, Andersen P (2010). T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection. Immunology 129(1):75-86.
Crossref
 
Launois P, Deleys R, Niang MN, Drowart A, Andrien M, Dierckx P, Cartel JL, Sarthou JL, Van Vooren JP, Huygen K (1994). T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy. Infect Immun. 62(9):3679-3687.
Pubmed
 
Lozes E, Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, Vandenbussche P, Van Vooren JP, Drowart A, Ulmer JB, Liu MA (1997). Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 15(8):830-833.
Crossref
 
Lu J, Wang C, Zhou Z, Zhang Y, Cao T, Shi C, Chen Z, Chen L, Cai C, Fan X (2011). Immunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein. Clin. Dev. Immunol. 2011:617892.
Crossref
 
Magalhaes I, Sizemore DR, Ahmed RK, Muellar S, Wehlin L, Scanga C, Weichold F,Schirru G, Pau MG, Goudsmit J, Kuhlmann-Berenzon S, Spangberg M, Andersson J, Gaines H, Thorstensson R, Skeiky YA, Sadoff J, Maeurer M (2008). rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. PLoS One 3(11):e3790.
Crossref
 
Pal PG, Horwitz MA (1992). Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect. Immun. 60(11): 4781-4792.
Pubmed
 
Rahman S, Magalhaes I, Rahman J, Ahmed RK, Sizemore DR, Scanga CA, Weichold F, Verreck F, Kondova I, Sadoff J, Thorstensson R, Spangberg M, Svensson M, Andersson J, Maeurer M, Brighenti S (2012). Prime-boost vaccination with rBCG/rAd35 enhances CD8+ cytolytic T-cell responses in lesions from Mycobacterium Tuberculosis -infected primates. Mol. Med. 18:647-658.
Crossref
 
Roberts AD, Sonnenberg MG, Ordwy DJ, Furney SK, Bernnan PJ, Belisle JT, Orme IM (1995). Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology 85(3): 502-508.
Pubmed
 
Rodrigues LC, Pereira SM, Cunha SS, Genser B, Ichihara MY, de Brito SC, Hijjar MA, Dourado I, Cruz AA, Sant'Anna C, Bierrenbach AL, Barreto ML (2005). Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: the BCG-REVAC cluster-randomised trial. Lancet 366(9493):1290-1295.
Crossref
 
Romano M, Roupie V, Wang XM, Denis O, Jurion F, Adnet PY, Laali R, Huygen K (2006). Immunogenicity and protective efficacy of tuberculosis DNA vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3. Immunology 118(3):321-332.
Crossref
 
Spencer AJ, Hill F, Honeycutt JD, Cottingham MG, Bregu M, Rollier CS, Furze J, Draper SJ, Sogaard KC, Gilbert SC, Wyllie DH, Hill AV (2012). Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. PLoS One 7(3):e 33555.
 
Sugawara I, Udagawa T, Taniyama T (2007). Protective efficacy of recombinant (Ag85A) BCG Tokyo with Ag85A peptide boosting against Mycobacterium tuberculosis-infected guinea pigs in comparison with that of DNA vaccine encoding Ag85A. Tuberculosis (Edinb). 87(2):94-101.
Crossref
 
Tanghe A, Denis O, Lambrecht B, Motte V, van den Berg T, Huygen K (2000). Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment. Infect. Immun. 68(7):3854-3860.
Crossref
 
Wang C, Fu R, Chen Z, Tan K, Chen L, Teng X, Lu J, Shi C, Fan X (2012). Immunogenicity and protective efficacy of a novel recombinant BCG strain overexpressing antigens Ag85A and Ag85B. Clin. Dev. Immunol. 2012: 583838.
Crossref
 
Xie Y, Bao L, Hu C, Zhang W, Chen W (2002). Molecular cloning and expression of the immunodominant protein Ag85A from Mycobacterium tuberculosis H37Rv strain. Hua Xi Yi Ke Da Xue Xue Bao 32(2):172-174.