African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Diketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activity

Luiza Guimarães Tunes
  • Luiza Guimarães Tunes
  • Genômica Funcional e Proteômica de Leishmania ssp. e Trypanosoma cruzi, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Google Scholar
Vívian Nicolau Gonçalves
  • Vívian Nicolau Gonçalves
  • Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Google Scholar
Daniela Nabak Bueno
  • Daniela Nabak Bueno
  • Laboratório de Química de Produtos Naturais Bioativos, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Google Scholar
Carlos Leomar Zani
  • Carlos Leomar Zani
  • Laboratório de Química de Produtos Naturais Bioativos, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Google Scholar
Luiz Henrique Rosa
  • Luiz Henrique Rosa
  • Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Google Scholar
Betania Barros Cota
  • Betania Barros Cota
  • Laboratório de Química de Produtos Naturais Bioativos, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Google Scholar


  •  Received: 26 June 2019
  •  Accepted: 26 August 2019
  •  Published: 31 October 2019

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Khamthong N, Rukachaisirikul V, Phongpaichit S, Preedanon S, Sakayaroj J (2012). Bioactive polyketides from the sea fan-derived fungus Penicillium citrinum PSU-F51. Tetrahedron 68(39):8245-8250.
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Kumar SN, Siji JV, Nambisan B, Mohandas C (2012). Activity and synergistic antimicrobial activity between diketopiperazines against bacteria in vitro. Applied Biochemistry and Biotechnology 168(8): 2285-2296.
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Roy G, Dumas C, Sereno D, Wu Y, Singh AK, Tremblay MJ, Ouellette M, Olivier M, Papadopoulou B (2000). Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models. Molecular Biochemical Parasitology 110(2):195-206.
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Siqueira-Neto JL, Song OR, Oh H, Sohn JH, Yang G, Nam J, Jang J, Cechetto J, Lee CB, Moon S, Genovesio A, Chatelain E, Christophe T, Freitas-Junior LH (2010). Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. PLoS Neglected Tropical Diseases 4(5):e675.
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Teixeira MC, De Jesus SR, Sampaio RB, Pontes-De-Carvalho L, Dos Santos WL (2002). A simple and reproducible method to obtain large numbers of axenic amastigotes of different Leishmania species. Parasitology Research 88(11):963-968.
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Wang J, Zhao Y, Men L, Zhang Y, Liu Z, Sun T, Geng Y, Yu Z (2014). Secondary metabolites of the marine fungus Penicillium chrysogenum. Chemistry of Natural Compounds 50(3):405-407.
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Wang N, Cui CB, Li CW (2016). A new cyclic dipeptide penicimutide: the activated production of cyclic dipeptides by introduction of neomycin-resistance in the marine-derived fungus Penicillium purpurogenum G59. Archives of Pharmacal Research 39(6):762-770.
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Wollinsky B, Ludwig L, Hamacher A, Yu X, Kassack MU, Li SM (2012). Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides. Bioorganic & Medicinal Chemistry Letters 22(12):3866-3869.
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Ying M, Liu Q, Chen L, Zheng Q, Zhou T (2015). Penicitrinine A derived from Penicillium citrinum, and application thereof in preparation of medicines for treatment of human colorectal cancer. Faming Zhuanli Shenqing CN 105061444 A 20151118.

 
 

Zheng Q, Liu Q, Chen Li, Ying M, Zhou Tong (2015). Penicitrinine A derived from Penicillium citrinum, and application thereof in preparation of medicines for treatment of nasopharyngeal carcinoma. Faming Zhuanli Shenqing CN 105061446 A 20151118.