African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

1-Indanone chalcones and their 2,4-Dinitrophenylhydrazone derivatives: Synthesis, physicochemical properties and in vitro antibacterial activity

Olatomide A. Fadare
  • Olatomide A. Fadare
  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
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David A. Akinpelu
  • David A. Akinpelu
  • Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
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Henry Ejemubu
  • Henry Ejemubu
  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
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Craig A. Obafemi*
  • Craig A. Obafemi*
  • Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
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  •  Received: 20 February 2014
  •  Accepted: 03 April 2014
  •  Published: 30 April 2014

Abstract

Chalcones are natural biocides. Several publications appear every year covering the synthesis of chalcones because they exhibit an array of pharmacological activities. In this study, some condensation reactions of 1-Indanone with substituted benzaldehydes were carried out under different reaction conditions. The chalcone products were converted to their corresponding 2,4-Dinitrophenylhydrazone derivatives and evaluated against five gram-positive and eight gram-negative bacteria for their in vitro antibacterial property. Antimicrobial activity was observed against many of the tested strains, with zones of inhibition ranging from 10 to 28 mm. In many cases, the hydrazone derivatives were more active than their chalcone precursors. The best results were obtained against gram-negative bacteria for most of the compounds. Compound 1b was the most active with its minimum inhibitory concentrations (MICs) against six strains of bacteria ranging from 15.6 to 31.3 µg/ml, hence, could be developed as an antibacterial agent against infections caused by some gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella typhimurium.

Key words: Antibacterial activity, chalcones, 2,4-Dinitrophenylhydrazones, 1-Indanone, microwave-assisted synthesis, minimum inhibitory concentration.