Abstract

Paramphistomiasis causes enteritis and anemia in livestock and result in substantial production and economic losses. It is considered a neglected tropical disease, with lower effective trematodicidal compound for treatment. Keeping in view the importance of disease, the present study aims to evaluate the efficacy of oxyclozanide and niclosamide, as well as a combination of both drugs in treatment of Paramphistomum infection. Twenty buffalo males of native breed between eight months to 2 years of age, naturally infected with Paramphistomeswere treated. Oxyclozanide and niclosamide were administered in 20 ml/100 kg and 125 mg/kg orally, respectively. The efficacies of the drugs were estimated on the bases of reduction in body weight, drug efficacy, paramphistomes egg count per gram feces, as well as, hematological and biochemical parameters. The obtained results revealed that Co administration of oxyclozanide and niclosamide resulted in amelioration of the most adverse effects associated with Paramphistomum infection and reflected significantly on decreased egg per gram count and oxidative stress, improved biochemical and hematological profiles.

Key words: oxyclozanide, niclosamide, antiparamphistomal, therapy, buffalo.