August 2013
Pattern of fatty acids as modulator for dietary iron overload and its influences on testicular function of experimental rats
An iron enriched diet was adopted by different health authorities as an effective tool to combat iron deficiency anemia. However, dietary fat may alter absorption and utilization of iron either in human or animal models. Being a potent pro-oxidant, iron can lead to generation of reactive oxygen species, inducing oxidative damage and inflammations in different tissues.. Present study aimed mainly to illustrate any...
August 2013
Sparfloxacin determination in bulk materials, pharmaceutical formulations and human serum by reverse phase HPLC method
A simple reverse phase high-performance liquid chromatography (HPLC) method was developed and validated for the quantitative determination of sparfloxacin (SPFX) in the bulk material, pharmaceutical formulation and human serum. Purospher Start C18 (25 cm × 4.6 mm, 5 µm) and Discovery C18 (25 cm × 4.6 mm, 5 µm) columns were used. The mobile phase, methanol, water and...
August 2013
Ototoxicity in tuberculosis treatment in South Africa: Exploring the current status
As a result of the known ototoxic effects of some of the medications used for tuberculosis (TB) treatment, healthcare workers involved in treating TB patients need to be aware of the ototoxic signs and when to refer to an audiologist for hearing monitoring. The main objective of the present paper was to determine the knowledge and management of ototoxicity related to TB treatment by South African healthcare workers....
August 2013
Assessment of toxicity in puffer fish (Lagocephalus lunaris) from South Indian coast
Puffer fish intoxication is one of the most common fish intoxications along the coasts of Asia.Lagocephalus lunaris is the most commonly available species in the South Indian coast and it is eaten by the locals. This study was undertaken to assess the risk of poisoning due to consumption of L. lunaris collected along the Southeast Indian coast. Swiss albino mice were intraperitoneally injected daily with...
August 2013
Evaluation of oxyclozanide and niclosamide combination as alternative antiparamphistomal therapy in buffaloes
Paramphistomiasis causes enteritis and anemia in livestock and result in substantial production and economic losses. It is considered a neglected tropical disease, with lower effective trematodicidal compound for treatment. Keeping in view the importance of disease, the present study aims to evaluate the efficacy of oxyclozanide and niclosamide, as well as a combination of both drugs in treatment...
August 2013
Acute modulation of rat plasma glucose byan aqueous garlic extract
In this study, the putative antidiabetic effect of garlic was re-investigated. Aqueous crude garlic solution was prepared at high concentration (2 g/ml) and extracts were obtained by ethanol precipitation followed by chromatography on C18 Sep-Pak cartridge. Garlic or extracts were administered by single intraperitoneal injection to euglycaemic rats. Plasma glucose, insulin and nitric oxide (NO) were determined after 30...
August 2013
Anxiolytic- and antidepressant-like effects of the ethanolic extract from Citrus limon plant widely used in Northeastern Brazil
Anxiolytic and antidepressant effects and acute toxicity of ethanolic extract (EE) from Citrus limon were studied in mice. Anxiolytic activity was evaluated using open field and elevated plus-maze tests. The antidepressant effect of the extract was studied by forced swimming test in mice. Phytochemical screening of the ethanolic extracts indicated the presence of cumarin and triterpenoids/steriods. In the open...
August 2013
Analgesic and neuromodulatory effects of sea anemone Stichodactyla mertensii (Brandt, 1835) methanolic extract from southeast coast of India
The biological activity of crude methanolic extract (CME) of sea anemone Stichodactylamertensii was screened. The CME was fractionated using diethylaminoethyl (DEAE – cellulose) and screened for hemolytic activity, mice bioassay, analegsic activity and neuromodulatory activity. The presence of protein was...
August 2013
Development and comparative evaluation of extended release indomethacin capsules
The aim of this study was to develop a new extended release capsules of indomethacin. The formulation has been prepared to enhance its dissolution which could provide better oral absorption of indomethacin (IND). Therefore, the effects of the component nature, their proportion in the release rate and the dissolution mechanism were investigated. Extended release capsules of IND were prepared by physical mixing using...
August 2013
An audit of drug consumption and wastage during subarachnoid block
Our aim was to estimate the amount of anaesthetic drug wastage during spinal anaesthesia in the operation room of a tertiary hospital and suggest ways of reducing such wastage. The study is a retrospective survey conducted using the anaesthesia records. Drug wastage was considered as the amount of drug left unutilized in the vials after completion of a procedure. An estimation of the cost of wasted...
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