African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 August, 2013; 7(30)

August 2013

Pattern of fatty acids as modulator for dietary iron overload and its influences on testicular function of experimental rats

An iron enriched diet was adopted by different health authorities as an effective tool to combat iron deficiency anemia. However, dietary fat may alter absorption and utilization of iron either in human or animal models. Being a potent pro-oxidant, iron can lead to generation of reactive oxygen species, inducing oxidative damage and inflammations in different tissues.. Present study aimed mainly to illustrate any...

Author(s): Mohamed M. Elseweidy, Mervat E. Asker, Sousou I. Ali, HebatAllah H. Atteia and Hala Soliman    

August 2013

Sparfloxacin determination in bulk materials, pharmaceutical formulations and human serum by reverse phase HPLC method

A simple reverse phase high-performance liquid chromatography (HPLC) method was developed and validated for the quantitative determination of sparfloxacin (SPFX) in the bulk material, pharmaceutical formulation and human serum. Purospher Start C18 (25 cm × 4.6 mm, 5 µm) and Discovery C18 (25 cm × 4.6 mm, 5 µm) columns were used. The mobile phase, methanol, water and...

Author(s): Somia Gul, Najma Sultana, M. Saeed Arayne, Sana Shamim, and Mahwish Akhtar,    

August 2013

Ototoxicity in tuberculosis treatment in South Africa: Exploring the current status

As a result of the known ototoxic effects of some of the medications used for tuberculosis (TB) treatment, healthcare workers involved in treating TB patients need to be aware of the ototoxic signs and when to refer to an audiologist for hearing monitoring. The main objective of the present paper was to determine the knowledge and management of ototoxicity related to TB treatment by South African healthcare workers....

Author(s): Katijah Khoza-Shangase    

August 2013

Assessment of toxicity in puffer fish (Lagocephalus lunaris) from South Indian coast

Puffer fish intoxication is one of the most common fish intoxications along the coasts of Asia.Lagocephalus lunaris is the most commonly available species in the South Indian coast and it is eaten by the locals. This study was undertaken to assess the risk of poisoning due to consumption of L. lunaris collected along the Southeast Indian coast. Swiss albino mice were intraperitoneally injected daily with...

Author(s): Niharika Mandal, Soumya Jal, K. Mohanapriya and S. S. Khora    

August 2013

Evaluation of oxyclozanide and niclosamide combination as alternative antiparamphistomal therapy in buffaloes

Paramphistomiasis causes enteritis and anemia in livestock and result in substantial production and economic losses. It is considered a neglected tropical disease, with lower effective trematodicidal compound for treatment. Keeping in view the importance of disease, the present study aims to evaluate the efficacy of oxyclozanide and niclosamide, as well as a combination of both drugs in treatment...

Author(s): Shaheen H., Kadry M. Sadek and Eman K. Bazh    

August 2013

Acute modulation of rat plasma glucose byan aqueous garlic extract

In this study, the putative antidiabetic effect of garlic was re-investigated. Aqueous crude garlic solution was prepared at high concentration (2 g/ml) and extracts were obtained by ethanol precipitation followed by chromatography on C18 Sep-Pak cartridge. Garlic or extracts were administered by single intraperitoneal injection to euglycaemic rats. Plasma glucose, insulin and nitric oxide (NO) were determined after 30...

Author(s): Meherzia Mokni, Sonia Hamlaoui, Ferid Limam, Mohamed Amri and Ezzedine Aouani    

August 2013

Anxiolytic- and antidepressant-like effects of the ethanolic extract from Citrus limon plant widely used in Northeastern Brazil

Anxiolytic and antidepressant effects and acute toxicity of ethanolic extract (EE) from Citrus limon were studied in mice. Anxiolytic activity was evaluated using open field and elevated plus-maze tests. The antidepressant effect of the extract was studied by forced swimming test in mice. Phytochemical screening of the ethanolic extracts indicated the presence of cumarin and triterpenoids/steriods. In the open...

Author(s): Francisco Rodrigo de Asevedo Mendes de Oliveira, Gilberto Santos Cerqueira,Rizângela Lyne Mendes de Freitas, Joaquim Soares Costa Júnior, Chistiane Mendes Feitosa and Rivelilson Mendes de Freitas    

August 2013

Analgesic and neuromodulatory effects of sea anemone Stichodactyla mertensii (Brandt, 1835) methanolic extract from southeast coast of India

The biological activity of crude methanolic extract (CME) of sea anemone Stichodactylamertensii was screened. The CME was fractionated using diethylaminoethyl (DEAE – cellulose) and screened for hemolytic activity, mice bioassay, analegsic activity and neuromodulatory activity. The presence of protein was...

Author(s): Sadhasivam Sudharsan, Palaniappan Seedevi, Umapathy Kanagarajan, Rishikesh S. Dalvi, Subodh Guptha, Nalini Poojary, Vairamani Shanmugam, Alagiri Srinivasanand Annaian Shanmugam    

August 2013

Development and comparative evaluation of extended release indomethacin capsules

The aim of this study was to develop a new extended release capsules of indomethacin. The formulation has been prepared to enhance its dissolution which could provide better oral absorption of indomethacin (IND). Therefore, the effects of the component nature, their proportion in the release rate and the dissolution mechanism were investigated. Extended release capsules of IND were prepared by physical mixing using...

Author(s): Buket Aksu, Aysu Yurdasiper, Mehmet Ali Ege, Neslihan Üstündağ Okur and H. Yesim Karasulu    

August 2013

An audit of drug consumption and wastage during subarachnoid block

Our aim was to estimate the amount of anaesthetic drug wastage during spinal anaesthesia in the operation room of a tertiary hospital and suggest ways of reducing such wastage. The study is a retrospective survey conducted using the anaesthesia records. Drug wastage was considered as the amount of drug left unutilized in the vials after completion of a procedure. An estimation of the cost of wasted...

Author(s): Amucheazi Adaobi Obianuju, Ajuzieogu Obinna V, Ezike HA and Onuora CE