African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Full Length Research Paper

Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats

Luciana da Silva Nunes Ramalho
  • Luciana da Silva Nunes Ramalho
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Gabriela Tafaela Dias
  • Gabriela Tafaela Dias
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Edla Julinda Ribeiro Coutinho Espinola Guedes
  • Edla Julinda Ribeiro Coutinho Espinola Guedes
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Micaelly da Silva Oliveira
  • Micaelly da Silva Oliveira
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Andressa Brito Lira
  • Andressa Brito Lira
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Kardilândia Mendes de Oliveira
  • Kardilândia Mendes de Oliveira
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Otemberg Souza Chaves
  • Otemberg Souza Chaves
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Josué do Amaral Ramalho
  • Josué do Amaral Ramalho
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Alexandre Rolim da Paz
  • Alexandre Rolim da Paz
  • Department of Medical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Janine Agra Padilha
  • Janine Agra Padilha
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Hilzeth de Luna Freire Pessoa
  • Hilzeth de Luna Freire Pessoa
  • Department of Biological Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Maria de Fátima Vanderlei de Souza
  • Maria de Fátima Vanderlei de Souza
  • Department of Pharmaceutical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Caliandra Maria Bezerra Luna Lima
  • Caliandra Maria Bezerra Luna Lima
  • Department of Physiology and Pathology, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Margareth de Fátima Formiga Melo Diniz
  • Margareth de Fátima Formiga Melo Diniz
  • Department of Pharmaceutical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar


  •  Received: 08 February 2019
  •  Accepted: 05 July 2019
  •  Published: 08 August 2019

Abstract

Sida rhombifolia L., popularly known in Brazil as "SIDA" or "mata-pasto", is considered a weed; a plant of the American continent and widely distributed in North Africa, belongs to the Malvaceae family. In Brazil, S. rhombifolia L. is scattered throughout the national territory, infesting agricultural crops. Certain species of the genus Sida, including S. rhombifolia, are widely used in Indian, Chinese, African and American medicine. The present study was carried out with the objective of evaluating the non - clinical acute toxicity of crude ethanolic extract (CEE) obtained from S. rhombifolia L. In treated males, there was a statistically significant reduction in water and feed intake. Biochemical analyzes showed statistically significant changes in the parameters of aspartate aminotransferase, alanine aminotransferase and creatinine; hematological parameters showed altered erythrocytes, mean corpuscular volume, mean corpuscular hemoglobin and eosinophil parameters; observed only in treated male animals. The animals' organs showed no significant changes. The results suggest that the ethanolic extract obtained from S. rhombifolia L. presents low acute dose toxicity. However, chronic toxicological studies should be performed to demonstrate the safety of long-term use of the drug.

Key words: Sida rhombifolia L., acute non-clinical toxicity, hematological parameters, biochemical analyses, histopathological parameters.