African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Full Length Research Paper

Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats

Luciana da Silva Nunes Ramalho
  • Luciana da Silva Nunes Ramalho
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Gabriela Tafaela Dias
  • Gabriela Tafaela Dias
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Edla Julinda Ribeiro Coutinho Espinola Guedes
  • Edla Julinda Ribeiro Coutinho Espinola Guedes
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Micaelly da Silva Oliveira
  • Micaelly da Silva Oliveira
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Andressa Brito Lira
  • Andressa Brito Lira
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Kardilândia Mendes de Oliveira
  • Kardilândia Mendes de Oliveira
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Otemberg Souza Chaves
  • Otemberg Souza Chaves
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Josué do Amaral Ramalho
  • Josué do Amaral Ramalho
  • PostGraduate Program in Technology Development and Innovation in Medicines, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Alexandre Rolim da Paz
  • Alexandre Rolim da Paz
  • Department of Medical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Janine Agra Padilha
  • Janine Agra Padilha
  • PostGraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Hilzeth de Luna Freire Pessoa
  • Hilzeth de Luna Freire Pessoa
  • Department of Biological Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Maria de Fátima Vanderlei de Souza
  • Maria de Fátima Vanderlei de Souza
  • Department of Pharmaceutical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Caliandra Maria Bezerra Luna Lima
  • Caliandra Maria Bezerra Luna Lima
  • Department of Physiology and Pathology, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar
Margareth de Fátima Formiga Melo Diniz
  • Margareth de Fátima Formiga Melo Diniz
  • Department of Pharmaceutical Sciences, Health Sciences Center, University of Paraiba, 58051-900 Paraiba, Brazil.
  • Google Scholar


  •  Received: 08 February 2019
  •  Accepted: 05 July 2019
  •  Published: 31 August 2019

References

Adeneye AA, Agbaje EO (2008). Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of Morinda Lucida Benth. in normal and alloxan-induced diabetic rats. African Journal of Biomedical Research 11(1).
Crossref

 

Agbor GA, Oben JE, Nkegoum B, Takala JP, Nigogang JY (2005). Hepatoprotective activity of Hibiscus cannabinus (Linn.) against carbon tetrachloride and paracetamol induced liver damage in rats. Pakistan Journal of Biological Sciences 8:1397-1401.
Crossref

 

Ajithabai MD, Rani S, Jayakumar G (2012). Review on the species of Sida used for the preparation of nayopayam kashayam. International Journal of Pharmaceutical Sciences and Research 2:173-195.

 

Almeida RN, Falcão ACGM, Diniz RST, Quintans-Júnior LJ, Polari RM, Barbosa-Filho, JM, Agra MF, Duarte JC, Ferreira CD, Antoniolli AR, Araújo CC (1999) Metodologia para avaliação de plantas com atividade no Sistema Nervoso Central e alguns dados experimentais. Revista Brasileira de Farmácia 80:72-76.

 

Almeida RBA, Carretto CFP, Santana RS, Furlan MR, Junqueira JC Jorge AOC (2008). Antimicrobial activity of Cymbopogon citratus (DC.) Staf on Candida spp. Journal of Dentistry, UNESP 37:147-153.

 

Auletta CS (1995). Acute, subchronic and chronic toxicology. CRC Press: London.

 

Baracho GS (1998). de. Taxonomy of the genus Sida L. section cordifolia (DC.) Fryxell (Malvaceae) in Brazil. Dissertation (Master in Botany), Recife-PE.

 

Basu SK, Rupeshkumar M, Kavitha K (2009) .Hepatoprotective and antioxidant effect of Andrographis echioides N. against acetaminophen induced hepatotoxicity in rats. Journal of Biological Sciences 9:351-356.
Crossref

 

Bessman JD, Gilmer PR, Gardner FH (1983). Improved classification of anemias by MCV and RDW. American Journal of Clinical Pathology 80:322-326.
Crossref

 

Brandt AP , Oliveira LFS, Fernandes FB, Alba J (2009) . Evaluation of prospective hypocholesterolemic effect and preliminar toxicology of crude extract and decoction from Vitex megapotamica (Spreng) Moldenke (V. Montevidensis Cham.) in vivo. Revista Brasileira de Farmacognosia 19(2):388-393.
Crossref

 

Brasil Resolução-RE nº90, de 16 de março de (2004). Guia para a realização de estudos de toxicidade pré-clinica.

 

Butler MS (2004). The role of natural product chemistry in drug discovery. The role of natural product chemistry in drug discovery. Journal of Natural Products 67(12):2141-2153.
Crossref

 

Castello BACS, Diniz MFFM , Almeida RN ,Santos HB , Oliveira KM , Ramalho JA, Dantas JD (2011). Biochemical and hematological parameters of Wistar rats and Swiss mice of the Vivarium Professor Thomas George. Brazilian Journal of Health Sciences 15:209-214.
Crossref

 

Chaves OS, Teles YCF, Monteiro MMO, Junior LGM , Agra MF, Braga VA ,Silva TMS, Souza MFV (2017). Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids. Molecules 22:94.
Crossref

 

Elisabetsky E (2001).Ethnopharmacology how to do research on active substances. In: SIMÕES CMO, Schenkel EP, Gosman G, Mello JC, MENTZ LA, Petrovick PR (eds). Farmacognosia: da planta ao medicamento. 3.ed. Porto Alegre: UFSC. p. 91-104.

 

El-sanusi NI, El-adam S (2007). The effect of low levels of dietary Ruta graveolens and Solenostemma argel or their mixture on bovans chicks. Asian Journal of Animal and Veterinary Advances 2:27-31.
Crossref

 

Fleck NG, Rizzardi MA, Agostinetto D, Vidal RA (2003). Seed production by black sting and guanxuma as a function of weed density and soybean sowing time. Plant Weed 21:191-202.
Crossref

 

França ISX, Souza JA, Baptista RSB, Britto VRS (2008) .Popular medicine: benefits and harms of medicinal plants. Brazilian Journal of Nursing, pp. 201-208.
Crossref

 

Galal A, Raman V, Khan IA (2015). Sida cordifolia, a Traditional Herb in Modern Perspective-A Review. Current Traditional Medicine 1:5-17.
Crossref

 

Giknis MLA, Clifford CB (2016). Clinical laboratory parameters for Crl:CD (SD) rats. Charles River Laboratories, pp. 1-18.

 

Heywood VH (1993). Flowering Plants on the World, Ed. B. T. Batsford Ltda., London.

 

Konaté K, Bassolé IHN, Hilou A, Aworet-Samseny RRR, Souza A, Barro N, Dicko MH, Jacques Y, Datté BM (2012). Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso. BMC Complementary and Alternative Medicine 12:1-11.
Crossref

 

Lewis RW, Billington R, Debryune E, Gamer A, Lang B, Carpanini F (2002). Recognition of adverse and nonadverse effects in toxicity studies. Toxicologic Pathology 30:66-74.
Crossref

 

Li X , Luo Y, Wang L, Li Y, Shi Y, Cui Y, Xue M (2010). Acute and subacute toxicity of ethanol extracts from Salvia przewalskii Maxim in rodents. Journal of Ethnopharmacology 131:110-115.
Crossref

 

Lorenzi TF (2006). Manual of hematology: propaedeutic and clinical. Guanabara Koogan 711 p.

 

Maciel MAM, Pinto AC, Veiga VF, Grynberg NF, Echevarria A (2002). Plantas medicinais: a necessidade de estudos multidisciplinares. Química Nova 25(3):429-438.
Crossref

 

Militão GCG, Dantas INF, Ferreira PMP, Alves APNN, Chaves DC, Monte FJQ. (2012). In vitro and in vivo anticancer properties of cucurbitacin isolated from Cayaponia racemosa. Pharmaceutical Biology 50:1479-1487.
Crossref

 

Mosallanejad B, Avizeh R, Varzi H (2011). Najafzadeh. Successful treatment of stanozolol induced-hepatotoxicity with silymarin in a bitch. Asian Journal of Animal Sciences 5:213-218.
Crossref

 

Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, Dorato M, Deun KV, Smith P, Berger B, Heller A (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology 32:56-67.
Crossref

 

Ouédraogo M, Zerbo P, Konaté K, Barro N, Sawadogo LL (2013). Effect of Long-term use of Sida rhombifolia L. Extract on Haemato-biochemical Parameters of Experimental Animals. British Journal of Pharmacology and Toxicology 4:18-24.
Crossref

 

Pradhan DK, Kumar PA, Kanta BR, Shivesh J, Ranjan MM, Ashutosh M, Sanjay C (2013). Ethnomedicinal and therapeutic potential of Sida acuta Burm. f. International Research Journal of Pharmacy 4:88-92.

 

Sireeratawong S, Nirush L, Umarat S, Amornat T, Anongnad N, Nadthaganya S, Jaijoy K Acute and subchronic toxicity study of the water extract from root of Sida rhombifolia Linn. in rats. Songklanakarin Journal of Science and Technology 30:729-737.

 

Stevens F (2003). Angiosperm Phylogenic, website.Version 4, Mayo 2003. 

View

 

Teo S, Stirling D, Thomas S, Hoberman A, Kiorpes A, Khetani VA (2002). A 90-day oral gavage toxicity study of d-methylphenidate and d, l-methylphenidate in Sprague-Dawley rats. Toxicology 179:183-96.
Crossref

 

Veiga VFJ, Pinto AC (2005). Maciel, M.A.M. Medicinal plants: safe cure. New Chemistry 28:519-528.
Crossref

 

World Health Organization (WHO) (2011). The World Medicines Situation 2011-Traditional Medicines: Global Situation, Issues and Challenges. World Health Organization: Geneva, Switzerland.