African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Chemical composition of essential oil of Melissa officinalis L. and antioxidant activity from Boa Vista-RR, Brazil

Ismael Montero Fernández
  • Ismael Montero Fernández
  • Department of organic and Inorganic Chemistry, University of Extremadura, Caceres, Spain.
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Pedro Rômulo Estevam Ribeiro
  • Pedro Rômulo Estevam Ribeiro
  • Post-graduate Program in Biodiversity and Biotecnology,State Coordination of Roraima, Federal University of Roraima,Campus Paricarana,Brazil.
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Selvin Antonio Saravia Maldonado
  • Selvin Antonio Saravia Maldonado
  • Faculty of Earth Sciences and Conservation, National University of Agriculture, Catacamas, Olancho, Honduras.
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Vany Perpetua Ferraz
  • Vany Perpetua Ferraz
  • Chromatography Laboratory, Institute of Exact Sciences,Department of Chemistry,UFMG,Belo Horizonte-MG Brazil.
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Ricardo Santos Alemán
  • Ricardo Santos Alemán
  • Department of Food Science, Louisiana State University, United States.
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Jhunior Abrahan Marcia Fuentes
  • Jhunior Abrahan Marcia Fuentes
  • Faculty of Technological Sciences, National University of Agriculture,Catacamas, Olancho, Honduras.
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Luis Antonio Beltrán Alemán
  • Luis Antonio Beltrán Alemán
  • Higher Tecnological Institute National Autonomous University of Honduras,Tela, Honduras.
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  •  Received: 10 February 2020
  •  Accepted: 16 March 2020
  •  Published: 30 April 2020


In this work, the chemical composition of the essential oil of lemon balm (Melissa officinalis L.) was determined by CG-FID.In the essential oil of M. officinalis,there area total of 22 chemical constituents, among them are geranial (34.6%), neral (26.0%), γ-caryophyllene (7.5%), caryophyllene oxide (5.3%), -pinene (5.3%) and sabinene (3.6%); it also has antioxidant capacity and total phenolic compounds in vitro. The concentration of total phenolic compounds was 61.71 mgEAG g-1 for the essential oil and 7.81 mgEAG g-1 for the aqueous extract respectively. The inhibition percentage tested by different DPPP concentrations of 8, 20, 40 and 80 µg mL-1 was 17.12, 31.04, 48.24 and 68.12% respectively and the quercetin standard was used as a positive control.

Key words: Limon herb, Folin-Ciocateau, DPPH, medicinal plant.