African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2191

Full Length Research Paper

Challenges of DOTS implementation strategy in the treatment of tuberculosis in a tertiary health institution, Ilorin, Nigeria

S. I. Bello
Department of Clinical Pharmacy and Pharmacy Administration, University of Ibadan, Ibadan, Oyo State, Nigeria
Email: [email protected]

  •  Accepted: 18 March 2010
  •  Published: 30 April 2010


Despite the fact that Directly Observed Treatment Strategy (DOTS) short course has recorded significant improvement in the tuberculosis (TB) disease detection, treatment and control in Nigeria, neither the set target for the TB detection rate nor the cure rate has been achieved nationwide, as several challenges detract its effective implementation. The objective of this study was to examine the challenges of DOTS implementation strategies in the treatment of TB patients with the view to determine factors militating against its effective implementation. Majority (75.3%) of the patients were within the age bracket of 16 - 45 years, while half (52.8%) of the patients that received proper counseling on medication at the hospital did not adhere to anti-TB drug dosage regimen. However, dark urine features prominently (72.1%) as side effects of anti-TB drugs among the patients followed by nausea and vomiting (25.4%), impaired vision (1.8%) and yellowish eyes (0.7%). There is a positive effect of finance on the TB patients and only very few patients could afford to purchase anti-TB drugs during stock-out due to financial constraints. Patients’ defaulted rates were 22.3 and 14% among the males and females respectively. Low treatment failure rates of 7.2 and 7.9% were also recorded in both men and women respectively. For effective DOTS strategy in eliminating TB nationwide, there is dire need for holistic approach in reaching all the patients with high-quality health care services even in the remote areas. Also, literacy level and social economic status of Nigerian citizens should be improved to enhance effective DOTS implementation. 


Key words: Tuberculosis treatment, DOTs strategy, Nigeria.