African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: April 2010; 4(4)

April 2010

Cosmeceuticals: A review

Cosmeceuticals are the latest addition to the health industry and are described as cosmetic products with drug-like activities. The term cosmeceutical was coined by Kilgman but these lines of product became popular in 1996 and have an expanding market that has rapidly reached Africa. Many scientists and health consumers in Africa may not be conversant with this line of products. They may therefore, be...

Author(s): Bello Shaibu Oricha

  • Article Number: C785C2F30539

April 2010

Comparing different sedation medications using generalized estimating equations approach

Generalized estimating equations (GEE) provides an applicable approach to modelling repeated and clustered data that are often encountered in medical application. This approach is very useful especially when response variables are correlated and categorical, covariates are time-depended, there are a large number explanatory variables and missing data. In this study, using this approach we focus on modelling repeated...

Author(s): M. A. Cengiz, T. Şenel, Y. Terzi, N. Murat and N. Savaş

  • Article Number: CE0BFE030568

April 2010

Evaluation of the antimicrobial activities of two Ziziphus species (Ziziphus mauritiana L. and Ziziphus spinachristi L.) on some microbial pathogens

The antimicrobial effects Ethanolic extracts of leaves of two species of genusZiziphus were determined against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Aspergillus niger and Candida albicans. S. pyogeneswas the most susceptible followed by E. coli while S. aureus was the least susceptible. The minimum inhibitory concentration (MIC) and the minimum...

Author(s): M. E. Abalaka, S. Y. Daniyan and A. Mann

  • Article Number: E82D45830602

April 2010

Antinociceptive and anti-inflammatory effects of the methanol seed extract of Carica papaya in mice and rats

The methanol seed extract of Carica papaya (CPE) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The brine shrimp lethality test of the extract showed LC50 of 106.94 ppm at 95% confidence interval. The extract (5, 10 and 20 mg/kg, p.o.) significantly (p < 0.05) increased pentobarbitone-induced sleeping time by more than 280% compared with the control. Like...

Author(s): A. O. Anaga and E. V. Onehi

  • Article Number: BBF857630639

April 2010

Effect of light irradiation on the antimicrobial activity of Zanthoxylum zanthoxyloides (lam) methanolic extract

The effect of light irradiation on the antibacterial potentials of methanol root extracts of Zanthoxylum zanthoxyloides (Linn) was evaluated against some clinical isolates of gram-positive and gram-negative microorganisms using the agar diffusion method. The methanol extracts were exposed to three different sources of radiations: sunlight (28 days), tungsten lamp (72 h) and photoreactor (1 h, 365 nm) after...

Author(s): Olayemi Modupe Adegbolagun and Oluwasola Omotayo Olukemi

  • Article Number: 98783E330677

April 2010

Plasmid DNA analysis and conjugative study of antibiotic resistant Salmonella typhi and paratyphi to ten selected antibiotics in Zaria, Nigeria

The antibiotic susceptibility of Salmonella typhi and Salmonella paratyphi isolates to ten selected antibiotics, plasmid DNA profiles and conjugative ability in Zaria, Nigeria were investigated. Blood samples collected from presumptive typhoid fever patients in the different locations were cultured for Salmonella species and identified by standard procedures. Susceptibility testing and...

Author(s): Adeshina Gbonjubola Olusesan, Osuagwu Nonyelum, Okeke Claire-Lorentz Ebere and Ehinmidu Joseph Olorunmola

  • Article Number: 9D3B90830721

April 2010

Challenges of DOTS implementation strategy in the treatment of tuberculosis in a tertiary health institution, Ilorin, Nigeria

Despite the fact that Directly Observed Treatment Strategy (DOTS) short course has recorded significant improvement in the tuberculosis (TB) disease detection, treatment and control in Nigeria, neither the set target for the TB detection rate nor the cure rate has been achieved nationwide, as several challenges detract its effective implementation. The objective of this study was to examine the challenges of DOTS...

Author(s): S. I. Bello

  • Article Number: 157745130773

April 2010

Evaluation of the antidiarrhoeal effect of Lannea welwitschii Hiern (Anacardiaceae) bark extract

Ethnopharmacological relevance encompasses the aqueous bark extract ofLannea welwitschii (Hiern), LW is used in Traditional African Medicine (TAM) for the treatment of diarrhea. However, the scientific basis for this usage has not been established. To evaluate the antidiarrhoel activity of LW using various pharmacological methods. The intestinal transit, castor oil induced diarrhea, enteropooling and gastric...

Author(s): Olufemi Olatokunboh Amole, Salahdeen Hussein Mofomosara and Onyeahialam Anthony Ekene

  • Article Number: 9E1AAFE30807

April 2010

Biological activity of progesterone-dihydropyridimidine derivative on perfusion pressure and coronary resistance in isolated rat heart

Experimental studies suggest that progesterone can regulate blood pressure. Nevertheless, there is scarce information about the effects of progesterone and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of progesterone at cardiovascular level is also unclear. In order, to clarify on those phenomena, we evaluated the effects of progesterone and...

Author(s): Figueroa Valverde Lauro, Guillermo Ceballos-Reyes, Francisco Díaz-Cedillo, Abelardo Camacho-Luis,  Maria López Ramos and G. Maldonado-Velazquez

  • Article Number: A86A25130843

April 2010

Effects of corn peptides on exercise tolerance, free radical metabolism in liver and serum glutamic-pyruvic transaminase activity of mice

In order to carry out research on the effects of corn peptides on exercise tolerance, free radical metabolism in liver and serum Glutamic-pyruvic transaminase (GPT) activity of mice, sixty Kun-Ming male mice were randomly divided into two experimental groups, that is , Group I (20 mice) and Group II (40 mice). Group Iwas a quiet group in which the mice were not trained; Group II was a...

Author(s): Fusheng Miao, Wenqian Yu, Yaoguang Wang, Meijuan Wang, Xiangyan Liuand Fenglin Li

  • Article Number: 372CB5C30873