African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2134

Full Length Research Paper

Effects of common daisy (Bellis perennis L.) aqueous extracts on anxiety-like behaviour and spatial memory performance in Wistar albino rats

F. Pehlivan Karakaş1*, A. Karakaş1, H. Coşkun2 and A. Uçar Turker1
1Department of Biology, Faculty of Arts and Sciences, Abant Izzet Baysal University, Bolu 14280, Turkey. 2Department of Psychology, Faculty of Arts and Sciences, Abant Izzet Baysal University, Bolu 14280, Turkey.
Email: [email protected]

  •  Accepted: 17 June 2011
  •  Published: 22 September 2011

Abstract

The effects of aqueous extract of flowers from Bellis perennis on anxiety-like behavior and memory in Wistar rats were tested. Vehicle 20 and 60 mg kg-1 B. perennis groups were performed and the animals were tested by open field and elevated plus maze tests for anxiety-like behaviour and Morris water maze test for spatial memory. In the open field, the high dose ofB. perennis administrated rats spent more time at the center, showed less mobility and velocity. In the elevated plus maze, the high dose of B. perennis administrated rats spent more time in the open arms, spent less time in the closed arms, were less mobile, were slower and rotated less frequently. In the Morris water maze, the high dose of B. perennis administrated rats spent more of the time to find the platform. In conclusion, B. perennis may produce biphasic effects on both anxiety-like behaviour and learning performance of the rats.

 

Key words: Bellis perennis, common daisy, anxiety, sedative, spatial memory.

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