African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Synthesis of three formamidine disulphide derivatives as potential integrase inhibitors of human immunodeficiency virus (HIV)

Afolabi Ezekiel O.* and Jegede Abiodun O.
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Jos, P.M.B. 2084, Jos, Plateau State, Nigeria.
Email: [email protected]

  •  Accepted: 28 December 2011
  •  Published: 22 May 2013

Abstract

Three analogues of formamidine disulphide (FMD) were synthesized as potential integrase inhibitor of human immunodeficiency virus (HIV). Piperonal, 3-Nitrobenz-aldehdye and 3,4,5-trimethoxybenzaldehyde, were respectively coupled with formamidine disulphide to prepare piperoformamidine disulphide (P-FMD), 3-Nitro-formamidine disulphide (N-FMD) and 3,4,5-trimethoxyformamidine disulphide (T-FMD). The structures of the three products were confirmed with infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry(MS) spectroscopic techniques, as reported.

 

Key words: Human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), formamidine disulphide (FMD).

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This article is published under the terms of the Creative Commons Attribution License 4.0

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