African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 22 May, 2013; 7(19)

May 2013

Advances in the study of the biological function of Daxx

Death domain-associated protein (Daxx) was originally identified as a protein that specifically binds to the death domain of the transmembrane death receptor Fas (also called CD95) in the cytoplasm and potentiates Fas-induced apoptosis. Over expression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx was found in the nuclears where it localizes to promyelocytic...

Author(s): Jinhong Liu, Guozuo Xiong, Duanfang Liao, , and Qinhui Tuo

May 2013

Antifungal activity of essential oil from Cinnamomum longepaniculatum leaves against three dermatophytes in vitro

The antifungal effects of essential oil from Cinnamomum longepaniculatum leaves were studied with special reference to minimal inhibitory concentration (MIC), minimal fungicidal concentration (MFC), time–kill studies and the mechanism of inhibition at ultrastructural level against Trichophyton mentagrophytes, Microsporum canis and Trichophyton gypseum. Its MICs against three important...

Author(s): Cui Tao, Qin Wei, Zhong-Qiong Yin, Li-Jun Zhou, Ren-Yong Jia, Jiao Xu, Dong-Xia Shi, Yi Zhou, Yong-Hua Du and Yun-Xia Deng

May 2013

Antifungal activity and gas chromatography coupled with mass spectrometry (GC-MS) leaf oil analysis of essential oils extracted from Eucalyptus globulus (Myrtaceae) of north centre region of Morocco

Essential oil from the leaves of Eucalyptus globulus collected in north centre region ofMorocco obtained by hydro-distillation were analyzed by gas chromatography equipped with flame ionisation detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). To evaluate the antifungal activities of these aromatic extracts, their in vitroantifungal activities...

Author(s): Elhoussine Derwich, Zineb Benziane, Rachida Chabir and Amina Bouseta

May 2013

Evaluation of antibacterial effect of monolaurin on Staphylococcus aureus isolated from bovine mastitis

Bovine mastitis is the inflammation of the parenchyma of the mammary glands of cattle associated with microbial infections. The most common bacteria causing bovine mastitis include; Staphylococcus aureus. Monolaurin, a food grade glycerol monoester of lauric acid, has been reported to have the greatest antimicrobial activity of all of the monoglycerides. The aim of this study was to evaluate of antibacterial effect...

Author(s): Khayatnouri MH and Topchi A

May 2013

Efficacy of losartan and combination of losartan plus hydrochlorothiazide for high blood pressure treatment


Author(s): Bunc Matjaž, ,  and Šušteršič Miha

May 2013

Lycium barbarum polysaccharides (LBP) extraction technology and its antioxidation activity

This study was carried out to investigate the technology of extracting Lycium barbarumpolysaccharide (LBP) and its antioxidation activity, using orthogonal experimental method to optimize its extraction conditions. Fenton reaction and pyrogallol experimental method were adopted to determine the antioxidation activity of LBP. The three factors investigated in the orthogonal experiment affected the results. Different...

Author(s): Ling Yuan, Yi Nan, Rong Wang and Yang Niu

May 2013

Expression of CD44 in osteoarthritis cartilage tissue and its clinical significance

The expression of CD44 in osteoarthritis cartilage tissue and its effect in the generation and development of osteoarthritis (OA) were studied. Forty patients with primary OA who received joint arthroplasty were randomly included in this study as OA group. The normal articular cartilages as control group were obtained following Outerbridge standard from twenty patients who received amputation. The...

Author(s): Bo Liao, Yong Ding, Yong Zhou, Baoan Ma and Yong Zhang

May 2013

Efficacy of different medicines used for the treatment of osteoporosis by using dual energy x-ray absorptiometry

Osteoporosis, a skeletal disease and common condition affecting one in three women and one in twelve men is a major health burden worldwide and in our population as well. A total of 180 patients including 30 in control group, 126 osteoporotics and 54 osteopenics, were diagnosed and analyzed with the help of bone mineral density (BMD) by dual energy x-ray absorptiometry (DEXA) and treated in different groups with...

Author(s): Perveen Zaidi, Muhammad Hanif, Shahid Kamal, Salman Habib and Akhtar Ahmed

May 2013

Synthesis of three formamidine disulphide derivatives as potential integrase inhibitors of human immunodeficiency virus (HIV)

Three analogues of formamidine disulphide (FMD) were synthesized as potential integrase inhibitor of human immunodeficiency virus (HIV). Piperonal, 3-Nitrobenz-aldehdye and 3,4,5-trimethoxybenzaldehyde, were respectively coupled with formamidine disulphide to prepare piperoformamidine disulphide (P-FMD), 3-Nitro-formamidine disulphide (N-FMD) and 3,4,5-trimethoxyformamidine disulphide (T-FMD). The structures of the...

Author(s): Afolabi Ezekiel O. and Jegede Abiodun O.

May 2013

Metabolic changes of glutathione in human T and B lymphocytes induced by organo-aluminum complex

Even though aluminium is not considered to be a heavy metal like lead, silver, arsenic and cadmium, it can be toxic when taken in excessive amounts and even in small amounts if deposited in the brain. Glutathione, a major antioxidant in the cells, so its depletion weakens the tissue resistance to oxidant. Glutathione is the sulfhydryl (-SH) antioxidant, antitoxin and enzyme cofactor which plays an important role in...

Author(s): Haroon Khan, Muhammad Farid Khan, Barkat Ali Khan, Naseem Ullah, Muhammad Mukhtiar and Arshad Farid