African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Preparation and evaluation of sustained release pellets of Tramadol

Nasim Sadri Alamdari1,2, Zahra Jafari Azar1, Jaleh Varshosaz3, Solmaz Ghaffari1,3,4,7*, Sanaz Ghaffari5 and Farzad Kobarfard6
1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University,Pharmacy Branch, Tehran, Iran. 2Quality Control Department, Jaber Ebne Hayyan Pharmaceutical Co. Tehran, Iran. 3Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran. 4Quality Control and R&D Departments, Iranian Parenteral and Pharmaceutical Co (I.P.P.C) Tehran, Iran. 5Young Researcher Club, Pharmacy Faculty, Islamic Azad University of Medical Sciences, Tehran. Iran. 6Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. 7Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences,Tehran, Iran.
Email: [email protected] or [email protected]

  •  Accepted: 21 May 2012
  •  Published: 29 April 2013

Abstract

Preparation of sustained release dosage forms is one of the main objectives in drug formulation. Tramadol is a centrally acting synthetic opioid analgesic used in treating severe pain. In this study, Tramadol sustained release pellets were prepared using two methods and the effect of type, ratio of polymers and plasticizers on drug loading and drug release profile was studied. From the results obtained, it seems that Eudragit RL is not a suitable choice and when Tween was used as plasticizer. Moreover, when mixture of Eudragit S and RS were applied as polymers, the optimum drug release profile was obtained and after 10 h, 95% of loaded drug was released.

 

Key words: Eudragit, Tramadol, sustained release, plasticizer, pellet.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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