African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 April, 2013; 7(16)

April 2013

Changes in plasma nitric oxide levels during migraine initial and attack periods in migraine patients

The most important primary headaches are migraine. Migraine has a prevalence of 10% in the general population and its societal costs are high. The precise mechanisms underlying the pathophysiology of migraine are still elusive. Nitric oxide (NO) is believed to play a key role in migraine pathogenesis. In this study, we compared migraine patients with healthy controls by measuring plasma nitrite levels in order to...

Author(s): Ulku Ozbey, Mine Erisir, Ayse Seyran and Fulya Benzer

April 2013

Anxiolytic activity of an aqueous extract of Alchornea cordifolia (Euphorbiaceae) leaves

Alchornea cordifolia, a half way growing shrub from Africa is very valued by traditional doctors in treating numerous ailments including psychical and nervous troubles. The aim of our study was to investigate the anxiolytic activity of A. cordifolia leaves by estimating the effect of an aqueous extract of this plant upon the spontaneous movements and the exploratory behaviour of...

Author(s): A. Kamenan, G. Kouakou-Siransy, Irié-Nguessan, I. Dally and J. Kablan Brou

April 2013

Effect of artesunate on the dissolution profile and antimicrobial activity of ciprofloxacin hydrochloride

This study evaluated the in vitro physico-chemical implication of co-presentation of ciprofloxacin with artesunate. Thin layer chromatography (TLC) and ultraviolet (UV) analysis was used to monitor the co-presentation of the two drugs. The in vitro dissolution profile of ciprofloxacin hydrochloride tablet in the presence of artesunate tablet was evaluated in buffer with pH 1.2 and water at...

Author(s): Olayemi Modupe Adegbolagun and Kate Ify Uyelumo

April 2013

Comparative excretion of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration

The aim of the present study was to characterize comparative excretion of pure vitexin-2"-O-rhamnoside (VR) in mice following oral and intravenous administration at dose of 30 mg/kg, therefore, a sensitive and specific high-performance liquid chromatography (HPLC) method using vitexin-4"-O-glucoside as internal standard developed and validated for quantitative analysis of VR. The results of...

Author(s): Ye An, Chaoshen Zhang, Yang Du, Lin Zhao, Zhongzhe Cheng, Wenjie Zhang, Xixiang Ying and Tingguo Kang

April 2013

Preparation and evaluation of sustained release pellets of Tramadol

Preparation of sustained release dosage forms is one of the main objectives in drug formulation. Tramadol is a centrally acting synthetic opioid analgesic used in treating severe pain. In this study, Tramadol sustained release pellets were prepared using two methods and the effect of type, ratio of polymers and plasticizers on drug loading and drug release profile was studied. From the results...

Author(s): Nasim Sadri Alamdari, Zahra Jafari Azar, Jaleh Varshosaz, Solmaz Ghaffari,, Sanaz Ghaffari and Farzad Kobarfard

April 2013

Phytochemical constituents and antidiarrhoeal effects of the aqueous extract of Terminalia superba leaves on Wistar rats

The aqueous extract of Terminalia superba leaves was subjected to phytochemical screening. Antidiarrhoeal property of the extract was determined at 50, 100 and 150 mg/kg body weight in castor oil-induced diarrhoeal Wistar rats. Phytochemical screening revealed the presence of saponins, cardenolides, triterpenes, flavonoids, steroids, phenolics and tannins, whereas alkaloids, anthraquinones and phlobatanins...

Author(s): Bamisaye F. A., Odutuga A. A., Minari J. B., Dairo J. O., Fagbohunka B.S and Oluba O.M.

April 2013

The comparison of multilevel models, method of moment and restricted maximum likelihood in assessing population bioequivalence

The determination of bioequivalence is very important in the pharmaceutical industries because the regulatory agencies like the Food and Drug Administration (FDA) allow a generic drug to be marketed only if its manufacturer can demonstrate that the generic product is bioequivalent to the brand-name product. Up to date, there is a lack of widely accepted statistical procedure for assessing population bioequivalence. We...

Author(s): Zhuo-Zhi Shen, Min Yang, Qiao-Lan Liu, Samir Mehta and Xiao-Song Li  

April 2013

Pharmacokinetics of omeprazole and its metabolites in premenopausal and postmenopausal females

The pharmacokinetic (PK) of omeprazole (OMP), 5-hydroxy-omeprazole (5-OH-OMP) and omeprazole sulphone (OMP-SUL), was investigated in healthy premenopausal and postmenopausal females. A single oral dose, open-label, non-controlled, pharmacokinetic study was conducted in healthy premenopausal (n = 16) and postmenopausal (n = 8) females. The samples were analyzed using reversed phase high performance liquid chromatography...

Author(s): Shabnam Nazir, Zafar Iqbal, Lateef Ahmad, Yasar Shah, Abad Khan, Fazli Nasir and Muhammad Akhlaq