Abstract

The Schiff base ligands, 4-(pyrrol-2-yl-methylen)amino-1-phenyl-2,3-dimethylpyrazolin-5-one (L1) and 2-hydroxyacetophenon-salcyl hydrazine (L2) have been synthesized by the condensation of 4-aminoantipyrine with pyrrole-2-carboxaldehyde and salicylic acid hydrazide with 2-hydroxyacetophenone, respectively. The Cu(II)and Mg(ІІ) complexes of these ligands have also been obtained. Their structure has been proven using spectral methods such as ultraviolet and visible absorption spectroscopy (UV-VIS), Fourier transform-infrared spectroscopy (FT-IR), ¹H-NMR and elemental analysis. The compounds were evaluated for toxicity degree and for their anti-inflammatory activity using carrageenan induces rat paw edema bioassay. All tested compounds are nontoxic at dose of 100 and 200 mg/kg. At dose of 400 mg/kg, the compounds have induced toxic central phenomena and the death occurred at dose of 800 mg/kg. At 8 h after the experiment started, some compounds showed anti-inflammatory effects comparable with the effect of indomethacin used as reference drug. The most active compound was Cu(II) complex (3) at  dose of 10 mg/kg.

Key words: Schiff base, ligand, transition metal, toxicity, anti-inflammatory effect.