African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2248

Table of Content: 29 May, 2013; 7(20)

May 2013

An invasive pneumococcal disease during the influenza pandemic successfully treated with ampicillin

We described the case of a 35-year-old man with a history of pulmonary tuberculosis, presented with invasive pneumococcal disease during the influenza pandemic. The patient recovered with ampicillin monotherapy; the differentials and the antibiotic choice for a fully penicillin susceptible strain of Streptococcus pneumoniae were discussed.   Key words: Streptococcus pneumonia bacteremia,...

Author(s): Camelia Gubavu, Liana-Catalina Gavriliu, and Gabriel-Adrian Popescu,

May 2013

Treatment of postanesthetic shivering in children: A randomized control study comparing tramadol to pethidine

Post-anaesthetic shivering (PAS) is a common and distressing complication, with most studies conducted in adults (Kranker et al., 2003). The aim of this study was to compare the effectiveness of tramadol and pethidine in the treatment of PAS in children. A randomized, double blind, comparative study was carried out on 80 children of American Society of Anesthesiologists (ASA) physical status I or II who presented with...

Author(s): Humphrey Ezike, Obinna Ajuzieogu, Adaobi Amucheazi, Richard Ewah and Jayne I. Ajuzieogu

May 2013

Chemical composition and biological screening of essential oils from Pistacia integerrima

The chemical composition and biological screening of the essential oils of the gall of Pistacia integerrima was performed. Volatile chemical constituents were obtained by hydrodistillation followed by liquid-liquid extraction. The oil was found rich in 1-Tepinen-4-ol (28.82%), p-meth-1-en-8-ol, (43.38%), n-Octyl acetate (19.91%), and beta-Farnesene (7.88%). The concentration of α-terpinolene,...

Author(s): Abdur Rauf, Ghias Uddin, Mohammad Arfan and Naveed Muhammad

May 2013

Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats

Humans are exposed to a number of toxic elements in the environment. Lead, widely used in industry, is a great environmental health problem of both humans and animals. Effects of reactive oxygen species (ROS) generation have been postulated to be major contributors to lead-exposure related disease. Effects of aqueous solution of whole ginger on hepatic injury due to lead-induced oxidative stress in experimental rats...

Author(s): Atef M. M. Attia, Fatma A. A. Ibrahim, Ghada M. Nabil and Samir W. Aziz

May 2013

Synthesis and biological evaluation of some new Schiff bases and their Cu(II) and Mg(ІІ) complexes

The Schiff base ligands, 4-(pyrrol-2-yl-methylen)amino-1-phenyl-2,3-dimethylpyrazolin-5-one (L1) and 2-hydroxyacetophenon-salcyl hydrazine (L2) have been synthesized by the condensation of 4-aminoantipyrine with pyrrole-2-carboxaldehyde and salicylic acid hydrazide with 2-hydroxyacetophenone, respectively. The Cu(II)and Mg(ІІ) complexes of these ligands have also been obtained. Their structure has been proven using...

Author(s): Gladiola Tantaru, Mihai Nechifor and Lenuta Profire

May 2013

Haematological and some biochemical profiles in male rats treated with Cnestis ferruginea (de Candolle) root extract and its pure fractions

The impact of methanolic root extract of Cnestis ferruginea on blood and some biochemical profiles was studied in male albino rats. Rats were treated with daily oral administration of the extract (500 mg kg-1 bw) and its pure fractions for 5, 30 and 60 days. Haematological indices and plasma concentrations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were not adversely affected...

Author(s): Funsho Olakitike Olayemi, Yinusa Raji, Olajire Aremu Adegoke and Mathew Olugbenga Oyeyemi

May 2013

The opportunities and challenges to introduce pharmaceutical care in Cuba

As with many countries across the globe, professional pharmacy is moving from a product orientation (dispensing medications) to a focus on patient care in Cuba. Such transformations are very difficult, especially for developing nation.  To alter the roles and responsibilities of pharmacists, Cuba is beginning to enhance existing practice settings, first with revamping educational programs.  The main change is...

Author(s): Martínez Sánchez and Alina de las Mercedes

May 2013

Evaluation of antimicrobial property of lichen- Parmelia perlata

The species of Parmelia mentioned in India Materia Medica are useful in treating a number of ailments and they are used in large quantities as food supplement in India. In this study, the crude extracts obtained from the Parmelia perlata by cold and hot extraction method using different solvents were tested for their antimicrobial activity. Results indicated that the antibacterial activity of P....

Author(s): Thippeswamy B, Sushma N. R. and Naveenkumar K. J.

May 2013

Inhibitory effect of alpha-momorcharin and its PEGylated conjugates on the migration and invasion of human choriocarcinoma JAR cells via reduced matrix metalloproteinase-2 (MMP-2) activity

Alpha-momorcharin (α-MMC) is a ribosome-inactivating protein (RIP) with antitumor and antiviral activities. α-MMC has a tumoricidal effect on choriocarcinoma, which is a malignant trophoblast-derived tumor that can arise during any type of gestation. To develop the therapeutic potential of α-MMC, we performed surface site-specific modification by covalent attachment of a 20 kDa amino derivative...

Author(s): Min Liu, Jieqing Hao, Bo Leng, Shurui Wang and Yanfa Meng

May 2013

Effectiveness of combined treatment using Spirulina and vitamin A against chronic arsenicosis in rats

Chronic arsenicosis remains a condition of public health concerns in many countries of the world and has been linked to many other diseases. This condition has been managed in humans using a combination of therapy with differing outcomes. We conducted a controlled experiment to assess the effect of chronic arsenicosis on hematological and biochemical changes in Long-Evans rats and to assess the protective role...

Author(s): Hossain F. M. A., Hossain M. M., Kabir M. G. and Fasina F. O.

May 2013

A report on the analysis of 365 cases of adverse reactions of Chinese patent drugs for heart cerebrovascular diseases

This research aimed to analyze the factors of heart cerebrovascular drugs that can lead to adverse reactions (ADRs) and to promote rational clinical drug use. Reports on cases of heart cerebrovascular diseases were collected in our hospital in 2001 to 2010, and medication and the clinical manifestations of the adverse reactions were analyzed. The incidence of adverse reactions was related with age, gender, routes of...

Author(s): Bin Xiang, Yong Peng and Yu-Gang Jiang

May 2013

Assessment of potential toxicity of three South African medicinal plants using the brine shrimp (Artemia salina) assay

As the use of medicinal plants increases, screening of their toxicity is crucial to guarantee the safety of the users. Hexane and acetone extracts of three South African plants, traditionally used for the management of opportunistic fungal infections in human immune deficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients were assayed for toxicity to hatching and larval mortality of Artemia...

Author(s): Wilfred M. Otang, Donald S. Grierson and Roland N. Ndip,

May 2013

Study on pharmacological mechanism of traditional Chinese medicine in intervention of cardiomyocyte apoptosis and targets prediction based on literature mining

The aim of this study is to predict possible apoptotic pathway and elucidate the multi-targets’ pharmacological mechanism of Chinese medicine in preventing and treating cardiovascular diseases through apoptosis pathway. Literature mining methods is applied to analyze literatures related to Chinese medicine with cardiomyocyte apoptosis in Chinese National Knowledge Infrastructure (CNKI) and pubmed database from the...

Author(s): Yulin Ouyang, Yong Wang, Xueling Ma, Chun Li, Wenjing Chuo, Shuzhen Guo, Wei Wang and Jianxin Chen

May 2013

Chemical composition and antidermatophytic activity of Nigella sativa essential oil

The essential oil of Nigella sativa extracted by standard hydrodistillation method from Cleavenger’s apparatus was done for Gas Chromatography (GC) and Gas Chromatography-Magnetic Separation (GC-MS) analysis. The oil yield was 0.35% (v/w) and had the presence of 17 volatile components representing 97.54% of the total oil which were identified. The major components of essential oil were para-cymene...

Author(s): Mahariya Sunita and Sharma Meenakshi

May 2013

Perinatal ethyl alcohol effects on the development of cerebellar cortex in albino rat

The present study aimed to show the effect of chronic low dose of ethyl alcohol on the cerebellar neurons in rat newborns. After birth, the newborns were divided into five groups: A, B, C, D and E. Group A is normal newborns while groups B, C, D and E are treated groups. The present results confirmed that ethanol during pregnancy has adverse effects on the neurogenesis of cerebellar cortex. These effects extended to the...

Author(s): Allam A., Abdul-Hamid M., Allam G. , Al-hroob A, Ibraheem G and Alsubaie M

May 2013

Ethyl alcohol administration during gestation disrupts development of sensorimotor reflexes and morphology of cerebral cortex and brachial spinal cord of albino rat newborns

The present investigation shows the effect of low dose of diluted ethyl alcohol (0.5 ml of 33% ethyl alcohol) on cerebral cortex, spinal cord and the development of sensorimotor reflexes in albino rat newborns. The newborns were divided into five groups A, B, C, D and E, each of 15 animals. Neuronal loss, oedema, pyknotic cells, vacuolation, neurocyte chromatolysis and dilated blood vessels were observed in cerebral...

Author(s): Allam, A., Ajarem, J., Abdul-Hamid, M. and Zoheir, K.,

May 2013

Effect of acrylamide on the development of medulla oblongata in albino rat: Biochemical and morphological studies

Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. The primary source of human exposure to acrylamide is occupational; other exposure sources include food, drinking water, and smoking. The present study was performed to investigate the effects of acrylamide on the development of the medulla oblongata and oxidative stress during pre- and perinatal maternal acrylamide exposure...

Author(s): Allam  A., El-Gareeb A, Abdul-Hamid M., El-Bakry A. and Ajarem J.

May 2013

“Development and evaluation of gastro-retentive drug delivery systems of cefuroxime axetil”

The aim of the present investigation was to increase the gastric residence time of cefuroxime axetil by preparing gastro retentive mucoadhesive tablet, thereby improving bioavailability of cefuroxime axetil. Tablets were prepared using different mucoadhesive polymers such as hydroxypropylmethyl cellulose K4M, carbopol 974P, sodium alginate, and chitosan in combination ratios by wet granulation method. All the batches...

Author(s): A. S. Gudigennavar, L. S. Vijapur, C. C. Patil and R. V. Kulkarni

May 2013

An isocratic liquid chromatography-electrospray ionization tandem mass spectrometric determination of varenicline in human plasma and dosage form

A simple, sensitive and accurate liquid chromatography tandem mass spectrometric (LC/MS/MS) method has been developed and validated for determination of varenicline (VRC) in human plasma and pharmaceutical tablets as a tool for therapeutic drug monitoring. The VRC and internal standard (paracetamol, IS) were extracted by liquid-liquid extraction technique. The separation was achieved on C18 column (150mm × 4.6 mm,...

Author(s): Mohammed G. Kassem, Mohammed W. Attwa, Ali S. Abdelhameed and Gamal A. E. Mostafa

May 2013

Multiresistant Staphylococcus intermedius isolated from otitis externa in dogs and them human owners – A practical approach

Staphylococcus intermedius is a commensal bacterium isolated from the mucous of clinically healthy dogs but commonly associated with pyoderma and otitis in dogs, causing opportunistic side infections. Otic exudates samples from 34 dogs affected by recurrent otitis externa and from 15 humans who had daily contact with them as pets were collected. Samples from five individuals who had no contact with any pet were...

Author(s): Romeo T. Cristina and Janos Degi

May 2013

Comparison of vaginal misoprostol application versus curettage in treatment of early pregnancy failure: A randomization clinical trial study

In this study, we examined the impacts of vaginal misoprostol versus curettage in treatment of early pregnancy failure in women with first time pregnancy. Sixty (60) pregnant women (30 women in misoprostol and 30 subjects in curettage group) with mean age of 25.8 ± 5.3 were enrolled in the research. Early pregnancy failure (less than 12 weeks) was confirmed by trans-vaginal sonography. Eight hundred (800...

Author(s): Zoleikha Atarod, Fatemeh Talebi, Seyyed Abbas Hashemi and Ali Kheradmand