African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Full Length Research Paper

Hypoglycaemic and hypolipidemic effects of pumpkin (Cucurbita pepo L.) on alloxan-induced diabetic rats

Asgary Sedigheh1,5, Moshtaghian Seyyed Jamal2, Setorki Mahbubeh3, Kazemi Somayeh4*, Rafieian-kopaei Mahmoud5, Adelnia Azadeh6 and Shamsi Fatemeh6
1Isfahan Cardiovascular Research Center and Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2Department of Biology, University of Isfahan, Isfahan, Iran. 3Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran. 4Department of Biology, University of Isfahan and Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 5Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran. 6Department of Biology, University of Payam-Noor, Isfahan, Iran
Email: [email protected]

  •  Accepted: 18 November 2011
  •  Published: 22 December 2011

Abstract

This study was aimed to evaluate the hypoglycaemic and hypolipidemic effects of different doses of pumpkin (Cucurbita pepo L.) powder in male diabetic rats. A total of 35 rats were randomized into 5 groups of 7 each as follows: Group 1: Normal control; Group 2: Diabetic control; Group 3: Diabetics administered with low doses of pumpkin powder (1 g/kg); Group 4: Diabetics administered with high doses of pumpkin powder (2 g/kg), and Group 5: Diabetics administered with glibenclamide (0.6 mg/kg), as positive control. The rats were made diabetic by alloxan (120 mg/kg body weight (BW)) injection and were treated for 4 weeks on a daily basis. Blood samples were collected following the experiment. Pancreatic specimens were also collected for histological analysis. Glucose, cholesterol, triglycerides, low density lipoprotein (LDL) and C-reactive protein (CRP) were significantly increased, while insulin was decreased in diabetic rats as compared to the normal control group (p < 0.05). Low dose pumpkin significantly decreased glucose, triglycerides, LDL and CRP as compared to diabetic group and high dose pumpkin decreased cholesterol (p < 0.05). Histological analysis also revealed a significant increase in the diameter and number of langerhans islets in treated group with pumpkin, which was consistent with the latter findings. Therefore, pumpkin might be beneficial in diabetic patients.

 

Key words: Cucurbita pepo, diabetes, pumpkin, alloxan monohydrate, rat, hypoglycaemic, hypoglycaemic.

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