African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2245

Full Length Research Paper

Formulation and evaluation of wound healing dermal patch

Nilani P.*, Pranavi A., Duraisamy B., Damodaran P., Subhashini V. and Elango K.
Department of Pharmacognosy, JSS College of Pharmacy, Off Campus of JSS University, Rocklands, Ootacamund, 643001 Tamilnadu, India.
Email: [email protected]

  •  Accepted: 08 August 2011
  •  Published: 08 September 2011

Abstract

In this study, the wound healing activity of total aqueous extract and the mucilage of leaves of plant Cocculus hirsutus (L) Diels was evaluated on excision wound model. Dermal films were prepared using total aqueous extract, mucilage and polyvinyl alcohol as a polymer base. The prepared polysaccharide solutions of the total extract and the isolated mucilage were evaluated for its physiochemical properties and total bacterial count. The prepared dermal patches were subjected biodegradation studies. The results indicate statistically significant wound healing response of the dermal patch containing the aqueous extract and the mucilage of leaves of plant C. hirsutus when compared with control group and groups subjected to standard marketed medicated dermal patch. The cost effective factor and biodegradation of the prepared dermal wound healing patch was also found to be significant.

 

Key words: Cocculus hirsutus (L.) Diels, wound healing, excision wound model, Dermal patches.