African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2248

Table of Content: 8 September, 2011; 5(9)

September 2011

Resistin as a new molecule

Adipose tissue, in addition to storing energy, secretes numerous factors implicated in modulating insulin, sensitivity and energy balance, such as leptin, adiponectin, TNF-α and resistin. Resistin, is a hormone that is produced by fatty cells, a recently described adipokine belonging to the cysteine-rich secretory protein family, was originally described as an adipocyte-derived polypeptide that links obesity and...

Author(s): Iclal GEYIKLI, and Muslum AKAN,

September 2011

Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

The present investigation was designed to evaluate the antibacterial, antifungal properties and physiochemical screening of the various leaves and stem extracts of Andrographis lineata. Acetone, ethanol, methanol, petroleum ether and chloroform extracts of shade dried plant leaf and stem of A. lineata were tested for antibacterial, antifungal and phytochemical analysis. The antibacterial properties of...

Author(s): Chinnappan Alagesaboopathi

September 2011

Recent advances on supercritical fluid extraction of essential oils

Supercritical fluid extraction (SFE) is one of the most commonly used extraction techniques in the course of analysis or preparation. It is environmentally friendly and has some advantages over other conventional extraction methods. This review covers the recent developments of SFE in the extraction of essential oils from the plant materials during the period 2005 to 2011, in particular some factors influencing SFE...

Author(s): Lili Xu, Xiaori Zhan, Zhaowu Zeng, Rong Chen, Haifeng Li, Tian Xie and Shuling Wang

September 2011

Gabaergic system role in aqueous extract of Valeriana officinalis L. root on PTZ-induced clonic seizure threshold in mice

Pharmacognosy studies have shown that Valeriana officinalis L. roots containing significant amounts of free amino acids such as GABA and other substances like valeric acid and isovalerate. In this study, anticonvulsant effects of V. officinalis (VO) roots aqueous extract, using standard methods of chemical seizure caused by pentylenetetrazole (PTZ) in mice was assessed. To evaluate mechanisms...

Author(s): Mir Hadi Khayat Nouri and Ali Namvaran Abbas Abad

September 2011

Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities

The aim of this study was to investigate the effects of 12 min run test on oxidative stress, some antioxidant enzyme activities, and muscle and DNA damage. Twenty two healthy and well trained male athletes were recruited to this study. The12 min run test, cooper test, was applied to the participating athletes. The blood samples were taken before, immediately after and 24 h after the run test, and sera and plasma were...

Author(s): Nazmi SaritaÅŸ, Fatma Uyanik, Zuhal Hamurcu and Bekir Çoksevim

September 2011

Effect of tetrandrine on the expressions of hypoxia-inducible factor-1α and vascular endothelial growth factor in neovascularized cornea

This study investigated the effect of tetrandrine on the expressions of hypoxia inducible factor1α (HIF1α) and vascular endothelial growth factor (VEGF) in neovascularized cornea of rats following alkaline burn. A rat model corneal neovascularization (CNV) was established by alkaline burn. The expressions of HIF1α and VEGF before and after tetrandrine treatment were detected by...

Author(s): Guangli Sun, Gang Su, Yu Zu, Mingchang Zhang and Qianqian Shi

September 2011

Preparation of mucoadhesive buccal patches of carvedilol and evaluation for in-vitro drug permeation through porcine buccal membrane

This investigation aimed at developing and evaluating mucoadhesive buccal patches of carvedilol. Permeation of carvedilol was calculated in vitro using porcine buccal membrane. Buccal formulations were developed by solvent-casting technique using chitosan as mucoadhesive polymer. The patches were evaluated for in vitro release, moisture absorption and mechanical properties. The optimized formulation,...

Author(s): Verma Navneet and Chattopadhyay Pronobesh

September 2011

In vitro antibacterial activities of crude aqueous and ethanolic extracts of the stem bark of Acacia mearnsii De Wild

The antibacterial activities of both water and ethanol extracts of Acacia mearnsii de Wild against Gram-positive and Gram-negative bacteria were investigated. The two extracts were very active against the two groups of bacteria. While the minimum inhibitory concentration (MIC) of the ethanol extract ranged between 78.1 and 625 µg/ml, the MIC for aqueous extract ranged between 156.3 and 625 µg/ml....

Author(s): O. O. Olajuyigbe and A. J. Afolayan

September 2011

Hepatoprotective and antioxidant effect of Sphenocentrum jollyanum (Menispermaceae) stem bark extract against CCl4- induced oxidative stress in rats

Methanolic stems bark extract of Sphenocentrum jollyanum (SBSJ) was evaluated for hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4) - induced hepatic damage in rats. The extract (50, 100 and 200 mg/kg) was administered orally to the animals with hepatotoxicity induced by CCl4 (30%, 1.0 ml/kg). In vitro antioxidant potential of the extract was evaluated by...

Author(s): O. S. Olorunnisola, Akintola A. O. and A. J. Afolayan

September 2011

Celastrol attenuates atherosclerosis in Apolipoprotein E (apoE) knockout mice fed an atherogenic diet

The study is aimed to investigate the effects of celastrol on the atherogenesis in apolipoprotein E knockout (apoE-/-) mice fed an atherogenic diet. All mice were fed a high-fat and high-cholesterol diet for 8 weeks. In the last 4 weeks, apoE-/- mice were randomly grouped to receive treatment with either celastrol (2 mg/kg/day in DMSO, i.p.) or vehicle DMSO (n=6 per group). Plasma lipids were determined...

Author(s): Jun Cheng#, Zhuo Tian#, Jinping Li and Houyuan Hu

September 2011

Formulation and evaluation of wound healing dermal patch

In this study, the wound healing activity of total aqueous extract and the mucilage of leaves of plant Cocculus hirsutus (L) Diels was evaluated on excision wound model. Dermal films were prepared using total aqueous extract, mucilage and polyvinyl alcohol as a polymer base. The prepared polysaccharide solutions of the total extract and the isolated mucilage were evaluated for its physiochemical...

Author(s): Nilani P., Pranavi A., Duraisamy B., Damodaran P., Subhashini V. and Elango K.