African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2195

Full Length Research Paper

The activity against methicillin-resistant Staphylococcus aureus and quantitative structure-activity relationship (QSAR) study of aza-naphthindolizinedione derivatives

Lin-Kun An1*, Zhan-Chao Li2, Xi-Wei Wu1, Xiao-Yong Zou2 and Lian-Quan Gu1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. 2School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Email: [email protected]

  •  Accepted: 18 April 2013
  •  Published: 08 May 2013

Abstract

The antibacterial activity of aza-naphthindolizinedione derivatives has been determined. Three compounds, 15, 21 and 40 exhibited strong inhibitory activity against Gram-positive bacterial strains and especially, showed 16 times activity better than vancomycin against methicillin-resistant Staphylococcus aureus (MRSA). Quantitative structure-activity relationship (QSAR) study indicated that the proposed method was a useful computational tool for prediction of antibacterial activity of aza-naphthindolizinedione derivatives. The molecular descriptors contained in the optimized descriptor subsets encoded information about the van der Waals volumes and AlogP of these derivatives and thus implied the relationship between these factors and antibacterial activity.

 

Key words: Aza-naphthindolizinedione derivative, antibacterial agent, methicillin-resistantStaphylococcus aureus, quantitative structure-activity relationship.