May 2013
Microsponges as promising vehicle for drug delivery and targeting: Preparation, characterization and applications
Development of novel drug delivery systems for optimization of drugs’ efficacy and cost-effectiveness has become highly competitive and rapidly evolving area of interest. Controlling the delivery rate of drugs to a predetermined site has been one of the biggest challenges faced by formulators. Amongst the novel drug delivery systems that proved their efficacy in achieving controlled drug release are microsponges....
May 2013
The effects of aqueous extracts of Hibiscus sabdariffa Linn. calyces of var. ruber and var. intermedius on intestinal transit in rats
The effects of aqueous extracts of Hibiscus sabdariffa l. calyces of var. ruber and var. intermedius on intestinal transit were determined in experimental rats. The dried calyces of H. sabdariffa l. were pulverized and 10% extracts of both var. ruber and var. intermedius were made and administered orally at varying doses. Test rats were given the 10% extracts...
May 2013
Assessment of the knowledge, attitude and awareness of residents of Jos, Plateau State, Nigeria, towards worm infestation and de-worming
Due to the poor socioeconomic conditions and severe lack of good hygienic living conditions in developing countries of the world, worm infestation has become widely prevalent and is a major public health problem. The purpose of this study was to assess the knowledge, attitude and practice of residents of Jos towards worm infestations and de-worming. This involved a cross-sectional study in urban slum of Jos North L.G.A...
May 2013
Effect of seawater immersion on the NF-κB, IκB and TLR4 expression in small intestinal tissues in rats with abdominal open injury
The aim of this study was to observe the impact of seawater immersion on the dynamic expressions of NF-κB and IκB mRNA in small intestinal tissues in rats with abdominal open injury. Wistar rats were randomly divided into three groups: the control group (n = 7), the abdominal open injury (AOI) group and abdominal open injury plus seawater immersion (AOI+SI) group. The dynamic expressions...
May 2013
Towards a new economic model on biopharmaceutical companies
Intangible assets are one of the most important issues in biopharmaceutical companiestoday, due to the idiosyncrasies of this business. In such an innovative sector, companies have been investing heavily in research, development and innovation and the book value often does not accurately reflect the real value of the companies. It was necessary, therefore, a new accounting model that meets the needs of this sector....
May 2013
Identification of errors in antibiotics’ prescriptions and prescription writing trends in areas of Hyderabad Sindh, Pakistan
Prescribing errors are common in hospitals and outpatient clinical settings. A number of studies have been performed regarding antibiotic prescription errors throughout the world but it is not yet enough in Hyderabad, Pakistan. This study was performed to identify the errors in antibiotics’ prescriptions and to propose the ways to minimize such errors. A total of 286 antibiotic containing prescriptions were...
May 2013
Antioxidant and anticancer activities of methanolic extract of Trollius chinensis Bunge
The flower of Trollius chinensis Bunge (Flos trollii) is used for treating upper respiratory infections, pharyngitis, tonsillitis and bronchitis as a Chinese folk medicine since ancient times. This study aimed to investigate possible antioxidant and anticancer activity of methanolic extract of F. trollii (FTME). The antioxidant activity of FTME was determined by...
May 2013
The activity against methicillin-resistant Staphylococcus aureus and quantitative structure-activity relationship (QSAR) study of aza-naphthindolizinedione derivatives
The antibacterial activity of aza-naphthindolizinedione derivatives has been determined. Three compounds, 15, 21 and 40 exhibited strong inhibitory activity against Gram-positive bacterial strains and especially, showed 16 times activity better than vancomycin against methicillin-resistant Staphylococcus aureus (MRSA). Quantitative structure-activity relationship (QSAR) study indicated that the proposed method...
May 2013
Inhibition of α-amylase and α-glucosidase activities by ethanolic extract of Amaranthus cruentus leaf as affected by blanching
This study investigated the inhibitory effect of Amaranthus cruentus leaf on key enzyme linked to type-2 diabetes (α-amylase and α-glucosidase) as well as assessing the effect of blanching (a commonly practiced food processing technique) of the vegetable on these key enzymes. Fresh leaves of A. cruentus were blanched in hot water for 10 min, and the ethanolic extracts of both the fresh...
May 2013
Effect of dexmedetomidine on myocardial oxygen consumption during extubation for old patients: A bispectral index-guided observation study
The aim of this study was to investigate the effect of dexmedetomidine (DEX) maintenance on myocardial oxygen consumption during extubation for generally-anesthetized old patients under bispectral index (BIS) monitoring. A total of 40 patients who were subjected to thyroid operation and laparoscopic cholecystectomy under general anesthesia (ASA I or II) were randomized into the experimental (n = 20) and control (n = 20)...
May 2013
Synthesis and characterization of folic acid-conjugated human serum albumin (HSA) nanoparticles for isoalantolactone cellular uptake in HeLa
Folic acid was previously demonstrated to mediate intracellular nanoparticle uptake. Isoalantolactone (IAL) was demonstrated to possess a variety of pharmacological activities in vivo and in vitro, including cytotoxic, diuretic and immunosuppressive activity. Here, we developed folic acid-conjugated human serum albumin nanoparticles for IAL (FHNs-IAL) encapsulation to improve the...
May 2013
Controlled release formulation of levocetirizine dihydrochloride by casein microparticles
The study aims to develop a microparticulate casein based delivery system by the controlled drug delivery approach using Levocetirizine dihydrochloride as the model drug. Fourier transform infrared spectroscopy (FTIR), X-ray and differential scanning calorimetry (DSC) studies substantially indicates the presence of molecularly dispersed drug within the particles with preserved...
May 2013
Molecular cloning and characterization of a new cDNA encoding a trypsin-like serine protease from the venom gland of Scolopendra subspinipes mutilans
A cDNA encoding a new putative serine protease, named Ssmase, was cloned and characterized from the venom gland of the centipede Scolopendra subspinipes mutilans. The cDNA sequence was 1029 bp length, including a 780 bp open reading frame (ORF), a 105 bp 5’ untranslated region, and a 144 bp 3’ untranslated region. The precursor nucleotide sequence of Ssmase was deduced to encode a...
May 2013
Simultaneous determination of organic acids and iridoid glycosides in traditional Chinese medicine (TCM) preparation reduning injection by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode
A sensitive method of the simultaneous determination of organic acids and iridoid glycoside in reduning injection was described by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode. RRLC separation was achieved by use of a C18 analytical column packed with sorbent of particle size 1.8 μm while the injected sample volume was set to 2 µl. A binary...
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