African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

In vivo radio imaging studies on designed swelling gastro retentive drug delivery system

Pradum Pundlikrao Ige1* and Surendra Ganeshlal Gattani2
1Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra 425405, India. 2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded, Dist. Nanded, Maharashtra 431606, India.
Email: [email protected]

  •  Accepted: 21 November 2013
  •  Published: 22 November 2013

Abstract

The objective of the study was to correlate the results of the in vitro release of a previously reported swelling gastro retentive drug delivery system with the in vivo radio imaging in rabbits. Tablets containing metformin hydrochloride evaluated for in vitro drug release profile showed drug release up to 14 h. Tablets containing barium sulfate was administered to rabbits after overnight fast. Radio imaging study showed that swelling matrix tablets remains in the upper small intestine of rabbit for the period of 10 h and it correlates with ex vivo retention time of 10 h.

Key words: Swelling matrix tablets, x-ray imaging, ex vivo-in vivo correlation.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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