Abstract

Two demineralized bovine bone membranes after cleaning and cutting into appropriated size, incorporated with doxycycline (DOX) and tetracycline (TET)were evaluated as controlled drug delivery devices and. The complete release time was 96 h (15 days) with a quick release in the first 12 h, decreasing exponentially to zero when it reaches 96 h. The release system fits in a pseudo second order kinetic model allowing the calculation of relevant parameters such as the initial release kinetics of the drug (h) with values ​​of 0.228 µg g^-1 h^-1 for DOX  and 0.625 µg g^-1h^-1 for TET, and a release rate constant (k) 37.66 g mg^-1 h^-1 for DOX and 43.03 g mg^-1h^-1for TET. The amount released by TET is higher than for the DOX in all the periods analyzed, but with the same desorption profile although any additional treatment on the membranes surface has been made. Both systems can be characterized as a controlled release device, due to  their effective retention even  long time after the start of experiment. Its use incorporated with antimicrobials agents is an important tool as physical barrier in periodontal regeneration to help combat periodontal pathogens and modulate the inflammatory response of the host, limiting tissue destruction.

Key words: Desorption kinetic, doxycycline, tetracycline, membranes, collagen and drug delivery.