July 2013
Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats
Medicinal herbs are commonly used worldwide as immune boosters and immunomodulators in the management of various disease conditions. Many of these herbs commonly used have not been scientifically evaluated for their immune modulating activities. The study investigated the immunomodulatory activity of the total crude leaf extract of Hibiscus sabdariffa in Wistar albino rats. It was an experimental study that...
July 2013
In vitro study of the desorption kinetic of doxycycline and tetracycline incorporated into collagen controlled released device (CRDs)
Two demineralized bovine bone membranes after cleaning and cutting into appropriated size, incorporated with doxycycline (DOX) and tetracycline (TET)were evaluated as controlled drug delivery devices and. The complete release time was 96 h (15 days) with a quick release in the first 12 h, decreasing exponentially to zero when it reaches 96 h. The release system fits in a pseudo second order kinetic model allowing...
July 2013
Activity induced by a progesterone derivative on injury by ischemia-reperfusion in an isolated heart model
Several studies indicate that some steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the effects of progesterone and its derivatives on cardiac injury ischemia/reperfusion (I/R). Therefore, in this study, a progesterone derivative was evaluated with the objective of evaluating its activity on I/R in an ischemia-reperfusion model. In addition, molecular mechanism...
July 2013
Preparation and characterization of orodispersible tablets of Meclizine Hydrochloride by wet granulation method
The aim of this research is to prepare orodispersible tablets of Meclizine Hydrochloride (MHCl). MHCl is used to treat or prevent nausea, vomiting, and dizziness. Wet granulation method was used to prepare the orodispersible tablets of MHCl using different super disintegrant; crospovidone (CP), sodium starch glycolate (SSG), croscarmellose sodium (CCS), and microcrystalline cellulose (MCC) at different concentrations....
July 2013
Lovastatin production using Pleurotus ostreatus and its medicinal properties analysis by docking
Lovastatin is an anti-lipidemic drug produced by various filamentous fungi as a secondary metabolite. In our study, Pleurotus ostreatus was used in the production of lovastatin by solid state fermentation process. P. ostreatus was grown on different substrate (wheat bran, rice bran, rice straw, sugarcane bagasse), from which the maximum yield was obtained when wheat bran was used as a substrate in...
July 2013
Bioactivity of gentamicin contained in novel transdermal drug delivery systems (TDDS) formulated with biodegradable polyesters
Topical administration of gentamicin, a hydrophilic aminoglycoside antibiotic, is limited by membrane impermeability and toxicity concerns. The purpose of this study was to develop and evaluate the antimicrobial activities of an alternative non-invasive, convenient and cost-effective transdermal drug delivery system (TDDS) containing gentamicin in biodegradable polyester-based matrices....
July 2013
Protective effects of aqueous extract of M. pruriens Linn. (DC) seed against cisplatin induced oxidative stress and nephrotoxicity in rats
In the present study, we investigated the effect of the aqueous extract of Mucuna pruriens, against cisplatin induced oxidative stress and nephrotoxicity in rats. Nephrotoxicity was induced by a single dose of cisplatin (5 mg/kg body weight i.p.). Cisplatin administration resulted in significant increases in urine volume, serum creatinine and urea and significant decrease in creatinine clearance and urinary...
July 2013
Biological screening of extracts of Brazilian Asteraceae plants
Natural products are a very productive source of leads for the development of medicines. Seven Brazilian Asteraceae adult plants were randomly chosen. The current study was designed to evaluate the antiprotozoal and cytotoxic activities in vitro of 21 extracts obtained. Phytochemical properties of the most active extracts also were checked. Cytotoxic activity was evaluated by...
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