African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Evaluation of anti-inflammatory activity of the bark of Eysenhardtia polystachya in experimental animal models

Rosa Martha Perez Gutierrez
  • Rosa Martha Perez Gutierrez
  • Laboratory of Research on Natural Products, School of Chemical Engineering and Extractive Industries del IPN Unidad Profesional Adolfo Lopez Mateos, Zacatenco, del IPN. Av. Instituto Politécnico Nacional S/N. CP.07508, México.
  • Google Scholar


  •  Received: 01 January 2015
  •  Accepted: 16 February 2015
  •  Published: 28 February 2015

Abstract

The bark of Eysenhardtia polystachya, has been used in Mexican folk medicine for treatment of anti-inflammatory diseases. This study aimed to investigate the anti-inflammatory activity, on various animal models using carrageenan-induced oedema, cotton pellets-induced granuloma, induction of acute inflammation by histamine, croton oil induced ear oedema, activity of myeloperoxidase, adjuvant-induced arthritis, quantification of tumor necrosis factors alpha (TNFα), interleukin-1 beta (IL-1β), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in arthritic rat. Methanol extract (PAM) was also performed by assessing the activities of lipoxygenase and xanthine-oxidase. Our data indicate that PAM exhibited significant anti-inflammatory activity in all the trials of paw and ear oedema induced exhibiting also anti-arthritic activity. PAM could also markedly inhibit production of proinflammatory cytokines, especially TNFα, IL-1β, PGE2 and LTB4. These effects resulted in an attenuation of the inflammatory cytokines and ultimately suppression of the oedema. The extract also inhibited lipoxygenase and xanthine-oxidase. It was seen that PAM is effective on chronic inflammation and acute inflammation.

Key words: Eysenhardtia polystachya, anti-inflammatory, cytokines, inflammation.