African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2156

Table of Content: 28 February, 2015; 9(8)

February 2015

Subchronic toxicity evaluation of the hydroethanolic extract from Endopleura uchi (Huber) Cuatrec in Wistar rats

Endopleura uchi (Huber) Cuatrec. (Humiriaceae) is a species from Brazilian Amazon rainforest, popularly used against menstrual disorders and uterine inflammation. This study aimed to evaluate the subchronic toxicity of hydroethanolic extract from E. uchi (EHEEu) in Wistar rats based on biochemical and hematological parameters. Rats were treated with daily doses of EHEEu (500 mg/kg - gavage), and then hematological and...

Author(s): Beatriz M. Sá, Clarissa S. Lima, Uriel Davi A. Silva, Helison O. Carvalho, Caio P. Fernandes, Rafael L. Resque, Tania T. de Oliveira and José Carlos T. Carvalho,

February 2015

Evaluation of anti-inflammatory activity of the bark of Eysenhardtia polystachya in experimental animal models

The bark of Eysenhardtia polystachya, has been used in Mexican folk medicine for treatment of anti-inflammatory diseases. This study aimed to investigate the anti-inflammatory activity, on various animal models using carrageenan-induced oedema, cotton pellets-induced granuloma, induction of acute inflammation by histamine, croton oil induced ear oedema, activity of myeloperoxidase, adjuvant-induced arthritis,...

Author(s): Rosa Martha Perez Gutierrez

February 2015

Review: The potential of chalcones as a source of drugs

Chalcone and dihydrochalcones are intermediates in the biosynthesis of flavonoids and isoflavonoids in plants. These compounds are widely investigated for their anticancer, anti-inflammatory, antimicrobial, antiprotozoal, antifilarial, larvicidal, anticonvulsant, anti-rheumatoid and antioxidant activities and their use as food additives. Chalcones are considered to be an active ingredient in a large number of medicinal...

Author(s): Rosa Martha Perez Gutierrez, Alethia Muñiz-Ramirez and Jahel Valdes Sauceda

February 2015

Clinical duration of rocuronium becomes shorter at night: A chronopharmacological study

The effects of circadian rhythms on the duration of neuromuscular blocking agents are under-investigated. Therefore, the aim of this prospective, observational study was to investigate whether the dosing-time of rocuronium would cause significant differences in the neuromuscular block duration during the four different period of a day in a diurnal based study design. Forty patients were allocated into one of the...

Author(s): Menekse Ozcelik, Ali Abbas Yılmaz, Sirali Oba, Sanem Turhan and Oya Ozatamer

February 2015

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Grapefruit (Citrus Paradise, family Rutaceae) is a citrus fruit that is low in calories and rich in dietary fibers. Sibutramine (Sibutramine hydrochloride monohydrate) is an anti-obesity drug that enhances satiety. The effect of grapefruit juice and sibutramine on body weight and neurotransmitters controlling appetite was investigated in obese rats.  Rats were assigned to two dietary groups for 3 weeks; control...

Author(s): Hadir Farouk, Sawsan S. Mahmoud, Bahia A. El-Sayeh, and Ola A. Sharaf