Abstract

Herbal preparations are commonly used by low-income populations to treat diabetes. The objective of this work was to evaluate interaction between Sarenta remedy with antidiabetic drug such as glibenclamide. Experimental study was carried out according to protocol described by Kambouche.  Before giving different solutions on study, baseline blood glucose was taken using "One call plus" glucometer, then glycaemia measure was determined every hour (T1h, T2h, T3h, T4h and T5h). Sarenta (3.33 mg b.w.) + glibenclamide (10 mg b.w.) significant decreased sugar blood at 1st to 2nd hour followed by hypoglycemia from 3rd to 5th hour. Glycemia reduction was respectively 24.83% (T2h); 37.66% (T3h); 46.50% (T4h) and 55.33% (T5h). Sarenta (6.66 mg b.w.) + glibenclamide (10 mg b.w.), also decreased glycaemia from 1st to 2nd hour around 15.41% (T2h), then reached normal value from 2nd to 5th hour. The last combination Sarenta (13.33 mg b.w.) + Glibenclamide (10 mg b.w.) had same effects as previously with normal glycaemia value close to 12.25% (T2h). Sarenta (6.66 and 13.33 mg b.w.) + glibenclamide 10 mg b.w. interaction lowered hyperglycemia without induced hypoglycemia. This euglycemic effect makes this remedy a potential phytomedicine candidate that could be combined with conventional drugs for diabetes treatment.

Key words: Blood sugar, conventional drugs, diabetes, interactivity.