African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2108

Full Length Research Paper

Cytotoxic oligostilbenes from Shorea hopeifolia

S. Rohaiza1, W. A. Yaacob1, L. B. Din1 and I. Nazlina2*
1School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia. 2School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Email: [email protected]

  •  Published: 15 September 2011

Abstract

Phytochemical and cytotoxicity investigations on the compounds from stem bark of Shorea hopeifolia were conducted. Four oligostilbenes of (-)-e-viniferin (1), (-)-ampelopsin E (2), (-)-hopeaphenol (3) and shoreaphenol (4) together with a coumarin of scopoletin (5) have been isolated and identified from the acetone extract of S. hopeifolia. The chemical structures of the isolated compounds were elucidated by spectroscopic methods including UV, IR, NMR and MS, and also by comparison with the literature data. Cytotoxic properties of the isolated compounds were evaluated against human hepatoma (HepG2) and Chang’s liver cells. The results indicated that compound 3 was most cytotoxic towards HepG2 cells with CC50 value of 4.5 mg/ml.

 

Key words: Dipterocarpaceae, Shorea hopeifolia, oligostilbenes, cytotoxicity.

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