African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 September, 2011; 5(10)

September 2011

Protection of α-tocopherol and selenium against acute effects of malathion on liver and kidney of rats

Protection from effects of the organophosphate insecticide, malathion on the liver and kidney of male Wistar albino rats by α-tocopherol and selenium was investigated. Significantly greater (P<0.01) mean concentrations of malondialdehyde (MDA) and lesser concentrations (P<0.01) of reduced glutathione (GSH) and tissues total proteins were observed in liver and kidney of rats exposed to malathion....

Author(s): Abdulaziz M. Al-Othman, Khaled S. Al-Numair, Gaber E. El-Desoky, Kareem Yusuf, Zeid A. Al Othman, Mourad A. M. Aboul-Soud, and John P. Giesy,,

September 2011

Literature review on pharmacological potentials of Kalanchoe pinnata (Crassulaceae)

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory...

Author(s): Subrata Kumar Biswas, Anusua Chowdhury, Joysree Das, S. M. Zahid Hosen, Riaz Uddin and Md. Shahedur Rahaman

September 2011

Cytotoxic oligostilbenes from Shorea hopeifolia

Phytochemical and cytotoxicity investigations on the compounds from stem bark of Shorea hopeifolia were conducted. Four oligostilbenes of (-)-e-viniferin (1), (-)-ampelopsin E (2), (-)-hopeaphenol (3) and shoreaphenol (4) together with a coumarin of scopoletin (5) have been isolated and identified from the acetone extract of S. hopeifolia. The chemical structures of the isolated compounds were elucidated...

Author(s): S. Rohaiza, W. A. Yaacob, L. B. Din and I. Nazlina

September 2011

A p53 codon 72 polymorphism associated with breast cancer in Iranian patients

The tumor suppressor gene p53 play general role in cell cycle control, the initiation of apoptosis, and in deoxyribonucleic acid (DNA) repair. The human p53 gene is mutated and accumulated in more than 50% of cancers. Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53 Arg72Pro polymorphism and...

Author(s): Abbas Doosti, Payam Ghasemi Dehkordi and Noushin Davoudi

September 2011

Pilot project for education of gestational diabetes mellitus (GDM) patients – Can it be beneficial?

The objective of this issue is to assess the effectiveness of an educational program on patients with gestational diabetes mellitus (GDM). The study design is a case-control study that includes30 pregnant women, mild GDM; between 19 and 41 years of age, without severe complications of diabetes. The women were divided into two groups – passing education Group I (n=15), and Group II (n=15), not passing...

Author(s): Valentina Petkova, Milen Dimitrov and Stanislav Geourgiev

September 2011

Prevalence, antibiotic susceptibility profile and extended spectrum β-lactamase production among Escherichia coli from high vaginal swab (HVS)

We examined the prevalence, antibiotic susceptibility profile and extended spectrum β- lactamase (ESBL) production by transitory Escherichia coli among other bacteria in vagina of female patients with symptoms of urinary tract infection, using standard microbiological methods. One hundred and forty-four patients’ samples were collected, of which 123 isolates were recovered. The age of the patients...

Author(s): Adegoke, Anthony A. and Okoh, Anthony I.

September 2011

The use of metronidazole and activated charcoal in the treatment of diarrhea caused by Escherichia coli 0157:H7 in an in vitro pharmacodynamic model

Activated charcoal (AC) has been utilized in the absorption of toxins from the intestinal tract of animals as well as humans. Some studies however have implied microbial adsorption at the interstices of AC surface. Activated charcoal has also been suggested and used as a treatment option for diarrhea. Metronidazole, a nitroimidazole derivative has been successfully utilized in the treatment of Clostridium...

Author(s): Ilomuanya M. O., Ifudu N. D. and Uboh C.

September 2011

Antioxidant activities of various fractions extracted from Astragalus

The antioxidant activities in vitro and in vivo assays of the four extracts from the herb ofAstragalus were investigated. 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assays were used to evaluate the antioxidant activities of the extracts in vitro. The effect of ethyl acetate extracts (EAE) in...

Author(s): Aoxue Luo and Yijun Fan

September 2011

Prevalence, types and predictors of potential drug-drug interactions in pulmonology ward of a tertiary care hospital

The objective of the study was to identify prevalence, types and predictors of potential drug-drug interactions (pDDIs) in pulmonology ward and to report common interactions. Medical records of 400 randomly-selected patients were reviewed for pDDIs using Micromedex Drug-Reax software. Logistic-regression was applied to determine predictors of pDDIs. We identified 126 interacting-combinations that encountered in total...

Author(s): Mohammad Ismail, Zafar Iqbal, Muhammad Bilal Khattak, Arshad Javaid and Tahir Mehmood Khan

September 2011

Correlation between clinicopathology and expression of heat shock protein 72 in human primary lung carcinomas

Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of different carcinomas, but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 in human primary lung carcinoma. The expression of HSP72 was studied in 96 human...

Author(s): Yan Fang, Xiao-Ping Wang, Huan-Ping Lin and Qiao-Xia Wang

  • Article Number: A02658233104

September 2011

Effect of tranilast on bleomycin induced pulmonary fibrosis in a rat model

This study aimed to investigate the effect and mechanism of tranilast (TR) on bleomycin (BLM) induced pulmonary fibrosis in a rat model, pulmonary fibrosis was induced in rats by using intratracheal bleomycin and the serum and lungs were collected 28 days later. The serum levels of IL-4 and IFN-γ were determined by ELISA and IL-4/IFN-γ was calculated. Reverse transcription polymerase chain reaction...

Author(s): Liantao Tang, Tao Jiang, Xiaoli Han and Dongling Chen

September 2011

Effects of acute high-intensity aerobic and anaerobic exercise on oxidative damage to lipids, proteins and DNA in untrained subjects

The purpose of this investigation was to determine the effects of aerobic and anaerobic exercise on oxidative damage to lipids, proteins and DNA. Fourteen untrained men performed an incremental exercise test to exhaustion and Wingate anaerobic test on two different occasions.Blood samples taken prior to the exercise, immediately post-exercise and 30 min post-exercisewere analyzed for plasma...

Author(s): Serkan Revan

September 2011

Effect of Salvia miltiorrhiza extract on blood lipid, hydroxyproline levels, skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats

The purpose of the present study was to examine the effects of aqueous extract of Salvia miltiorrhiza on plasma lipid and hydroxyproline levels and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats. Adult Sprague-Dawley male rats, 3 months of age, were assigned randomly to a sedentary control (n = 10) or exercise (n = 10) group or SME-treatent groups (exercise + SME) (n =...

Author(s): Cao Yun and Meng Tao