African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2200

Full Length Research Paper

Therapeutic effectiveness assessment of antiviral drugs used in chronic hepatitis treatment in three Ivorian university hospitals

Geneviève Amenan N’guessan-Irié
  • Geneviève Amenan N’guessan-Irié
  • Pharmacy Unit, University Hospital of Cocody, Côte d’Ivoire.
  • Google Scholar
Emile Allah-Kouadio
  • Emile Allah-Kouadio
  • Hepato-Gastro Enterology Unit, University Hospital of Cocody, Côte d’Ivoire.
  • Google Scholar
Christiane Ella Kogbahonon Allouka
  • Christiane Ella Kogbahonon Allouka
  • Laboratory of Pharmacology, Training and Research Unit of Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University, Côte d’Ivoire.
  • Google Scholar
Steven Driga Tchekpa Paul Kohi
  • Steven Driga Tchekpa Paul Kohi
  • Laboratory of Pharmacology, Training and Research Unit of Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University, Côte d’Ivoire.
  • Google Scholar
Bienvenu Oko Gnépéhi
  • Bienvenu Oko Gnépéhi
  • Laboratory of Pharmacology, Training and Research Unit of Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University, Côte d’Ivoire.
  • Google Scholar
Gisèle N’doua Siransy-Kouakou
  • Gisèle N’doua Siransy-Kouakou
  • Laboratory of Pharmacology, Training and Research Unit of Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University, Côte d’Ivoire.
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  •  Received: 18 October 2019
  •  Accepted: 25 November 2019
  •  Published: 31 December 2019

Abstract

This work aims to evaluate the effectiveness of drugs used for the management of chronic viral hepatitis in the three major university hospitals in Abidjan. This is a retrospective cross-sectional descriptive study of 203 patients investigated for treatment protocols, patient parameters before and after treatment. It emerged that treatment with pegylated Interferon alpha 2a resulted in a significant decrease in viremia for an average treatment duration of 48 weeks in patients with chronic viral hepatitis B; on the one hand, the combination of Ribavirin + pegylated Interferon alpha 2a, Ribavirin + Sofosbuvir and Daclatasvir + Sofosbuvir provided cure in patients with chronic viral hepatitis C for an average duration of treatment of 12 to 24 weeks. However, the cure of patients with chronic viral hepatitis C was mostly clinical. The examinations that could attest to the healing were not performed by most of the patients, due to the high costs of virologic and enzymatic ones. These results constitute an important database for the therapeutic survey of people with chronic viral hepatitis in Côte d'Ivoire and an additional argument to accelerate the general subvention for the management of these viral diseases.

Key words: Viral hepatitis B-C-D, antiviral drugs, virologic markers, enzymatic markers.