Abstract

This work aims to evaluate the effectiveness of drugs used for the management of chronic viral hepatitis in the three major university hospitals in Abidjan. This is a retrospective cross-sectional descriptive study of 203 patients investigated for treatment protocols, patient parameters before and after treatment. It emerged that treatment with pegylated Interferon alpha 2a resulted in a significant decrease in viremia for an average treatment duration of 48 weeks in patients with chronic viral hepatitis B; on the one hand, the combination of Ribavirin + pegylated Interferon alpha 2a, Ribavirin + Sofosbuvir and Daclatasvir + Sofosbuvir provided cure in patients with chronic viral hepatitis C for an average duration of treatment of 12 to 24 weeks. However, the cure of patients with chronic viral hepatitis C was mostly clinical. The examinations that could attest to the healing were not performed by most of the patients, due to the high costs of virologic and enzymatic ones. These results constitute an important database for the therapeutic survey of people with chronic viral hepatitis in Côte d'Ivoire and an additional argument to accelerate the general subvention for the management of these viral diseases.

Key words: Viral hepatitis B-C-D, antiviral drugs, virologic markers, enzymatic markers.