African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

Marcel S. Nascimento
  • Marcel S. Nascimento
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Igor O. Paiva-Souza
  • Igor O. Paiva-Souza
  • Pharmacology Laboratory Inflammatory Process, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Ximene A. Fernandes
  • Ximene A. Fernandes
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Sabrina Z. da C. de Moraes
  • Sabrina Z. da C. de Moraes
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Silvan S. Araújo
  • Silvan S. Araújo
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Andrea Y. K. V. Shan
  • Andrea Y. K. V. Shan
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Enilton A. Camargo
  • Enilton A. Camargo
  • Pharmacology Laboratory Inflammatory Process, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Antonio E. G. Santana
  • Antonio E. G. Santana
  • Natural Resources Laboratory, Institute of Chemistry and Biotechnology, Federal University of Alagoas (UFAL), University City A.C.Simões, Av. Lourival Melo Mota, s/n Tabuleiro dos Martins, Maceió, Alagoas, 57072-900, Brazil.
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Brancilene S. Araújo
  • Brancilene S. Araújo
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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Charles S. Estevam
  • Charles S. Estevam
  • Natural Products Chemistry Laboratory, Department of Physiology, Federal University of Sergipe (UFS), University City Prof. José Aloísio de Campos, Av. Marechal Rondon, s/n Jardim Rosa Elze, São Cristóvão, Sergipe, 49100-000, Brazil.
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  •  Received: 09 August 2016
  •  Accepted: 15 September 2016
  •  Published: 22 October 2016

Abstract

This study investigated the antioxidant and anti-inflammatory effects from the inner bark of Mimosa tenuiflora. The hydroethanol extract (HEE) and its hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fractions were prepared and submitted to phytochemical screening and antioxidant activity. In vivo anti-inflammatory effect was investigated by using 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced edema and myeloperoxidase (MPO) activity in mice ears. Phytochemical prospection of HEE revealed the presence of flavonoids, tannins, xantones, triterpenes, esteroids and phenols. Higher total phenol content was found in EAF and higher percentages of inhibition of 2,2-diphenyl-1-picrylhydrazyl free DPPH radical were found for HEE, EAF or HMF. Lipid peroxidation (LP) induced by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) was greatly inhibited by HEE or EAF, while inhibition of FeSO4 - induced LP was higher for HMF. The coadministration of HEE (1 or 3 mg/ear) decreased edema (p<0.001) and MPO activity (p<0.05). All fractions reduced mice ear edema at the same extent, however, while EAF and HMF reduced MPO activity in mice ear at both 1 and 3 mg/ear (p<0.001 and p<0.05 respectively), CLF only at 3 mg/ear (p<0.05) and HXF did not affect this parameter. Taken together, these results demonstrate that inner bark of M. tenuifolia possesses antioxidant and anti-inflammatory effects.

Key words: Mimosa tenuiflora, oxidative stress; inflammation, edema, myeloperoxidase activity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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