African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2241

Full Length Research Paper

Hospital antibiotic abuse and analysis of its adverse reactions

Yong Zhang* and Bin Guo
First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121001, China.
Email: [email protected]

  •  Accepted: 09 July 2012
  •  Published: 22 November 2012


The aim of this study was to analyze the use of antimicrobial drugs and assess the rationality of use of antimicrobial drugs. 433 random samples of hospital pharmacy prescription in June to August 2010 were selected, the prescriptions covered hospital representative subjects, the application of impatient antimicrobial drugs was described according to "Clinical Guide to Chinese Pharmacopoeia", "New Pharmacology", and the physicians’ prescriptive habits and the recommended dose of new drug instructions. The results have shown that among the selected 433 cases, the irrational ratio of utilization of antibiotics was 245 cases, accounting for 56.6% of the investigated prescription. Underuse, due to insufficient access to effective antibiotics, inadequate dosing and poor adherence to therapy, may play as important a role in driving resistance as overuse. This widespread irrational use of drugs is one of the most important reasons for antibiotics losing their effectiveness. The findings suggest that doctors should be cautious in using antimicrobial drugs, selecting the appropriate dosage forms and paying attention to the rational use of drugs so as to reduce the incidence rate of adverse reactions so as to regulate the application of antibacterial drugs.


Key words: Inpatient prescription, antimicrobial drugs, irrational, prescription analysis.