African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2157

Table of Content: 22 November, 2012; 6(43)

November 2012

Efficacy of Yan-Shen capsule on advanced chronic kidney disease (CKD) patients: An open, randomized, prospective, comparative study

This study aimed to investigate the efficacy of Yan-Shen capsule, a traditional Chinese medicine compound, on patients with advanced chronic kidney disease (CKD). A randomized prospective clinical trial was conducted to investigate the efficacy of Yan-Shen capsule on hospital patients with advanced CKD (stages III to IV). Each group included 82 patients (males and females), and all patients were followed...

Author(s): Fa-Huan Yuan#, Wei-Ping Hou#, Li-Xia Guang, Xiang Du and Rui Zhang

November 2012

The protective effect of salidroside on oxidative stress injury induced by hydrogen peroxide in PC12 cell

The protective effect of salidroside (SD) on oxidative stress injury induced by hydrogen peroxide in PC12 cell was investigated. The PC 12 cell was cultured in RPMI-1640 medium supplemented with 10% newborn calf serum at 37°C in a 5% CO2 incubator. 40 μM of H2O2was conducted to establish an oxidative-stress injury model in vitro. The effect of SD was evaluated by using the model. The LDH release...

Author(s): Xinwei Huang, Cuiling Wang, Ning Zhang and Jianli Liu

November 2012

Effect of recombinant human growth hormone (rhGH) on treatment of geriatric thoracic and abdominal postoperative patients with acute respiratory failure

The aim of this study was to explore the effect and ascertain the ideal dose of recombinant human growth hormone (rhGH) for the treatment of geriatric thoracic and abdominal postoperative patients with acute respiratory failure. Forty-five geriatric postoperative patients with acute respiratory failure were randomly divided into three groups (A, B and C). Patients in rhGH group A were...

Author(s): Chun-Feng Sheng, Zhi-Cheng Fang, Bo-Yi Liu, Min Fang, Pei Liu and Xiang Zheng

November 2012

Pharmacodynamic and pharmacokinetics of metronidazole in protein malnourished rats

The aim of this study is to evaluate the relationships between metronidazole toxicity and pharmacokinetics in protein malnourished rats. The study was carried out on two sets of rats, normally-fed set and protein malnourished set. Each set was divided into a control group and three-treated groups that received metronidazole daily in one dose of 200, 400 or 800 mg/kg for 30 days. Liver enzymes as well as testosterone and...

Author(s): Essam Ezzeldin,

November 2012

Children and adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) in the Eastern Cape, South Africa: Aetiology, diagnosis and treatment

The aim of the study was to investigate the aetiology, diagnosis and treatment of children and adolescents diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) in the Eastern Cape Province of South Africa. A questionnaire survey was conducted in 2007. A stratified random sample of pharmacies was selected. Fifty-four pharmacies indicated their willingness to participate in the study. Questionnaires were...

Author(s): Sanmari Snyman and Ilse Truter

November 2012

In vitro susceptibility of Mycobacterium tuberculosis to clarithromycin

This study was done to evaluate in vitro susceptibility of Mycobacterium tuberculosis of clarithromycin. In this prospective study, 90 M. tuberculosis strains (40 resistant strains and 50 susceptible strains) referred to the Tabriz laboratory of TB research Center were selected and cultured in L-J medium and with 3 doses of clarithromycin. 40 strains were resistant and 50 strains were...

Author(s): Mojtaba Varshochi, Hossein Najafian, Seyed Reza Moaddab and Behrooz Nagili

November 2012

Interference of amlodipine combined with ALT-711 on arteriosclerosis in spontaneously hypertensive rats

The objective of this study was to investigate the effect of amlodipine combined with ALT-711 on hypertension and the prevention of the complication of hypertension such as arteriosclerosis. Ten-week-old male spontaneously hypertensive rats (SHR) were randomly divided into four groups with six in each group: the blank control group (Group A, physiological saline 1 ml/kg/d), the amlodipine group (Group B, amlodipine 1...

Author(s): Chuanfeng Tong, Manma Xie and Jianghua Ren

November 2012

The protective effects of cinnamon and sugar tea extract on diabetic rats with interrelationships between oxidative stress and DNA damage

Diabetes mellitus (DM) is diagnosed by the presence of hyperglycemia, which leads to increased oxidative stress. In this study, we aimed to determine whether cinnamon and sugar tea extract have protective effects on streptozotocin (STZ)+nicotinamide-induced diabetic rats. The therapeutic potential of cinnamon and tea extract on DM was assessed through analysis of their effects on both oxidative stress and DNA damage....

Author(s): Özlem Sağlam, Irfan Değirmenci, Mehmet Cengiz Üstüner and Hasan Veysi Güneş

November 2012

Effect of terpene liposomes on the transdermal delivery of hydrophobic model drug, nimesulide: Characterization, stability and in vitro skin permeation

This study evaluates the ability of the terpenes incorporated in liposomes on the in vitro skin delivery of hydrophobic model drug, nimesulide (NE). To this purpose, so-called terpene liposomes (TPs), which are composed of phospholipid and three types of terpene, citral, limonene and cineole. The obtained formulations were characterized in terms of size distribution, zeta potential and morphology. The...

Author(s): Mohamed Badran, Gamal Shazly, and Mahmoud El-Badry,

November 2012

Hospital antibiotic abuse and analysis of its adverse reactions

The aim of this study was to analyze the use of antimicrobial drugs and assess the rationality of use of antimicrobial drugs. 433 random samples of hospital pharmacy prescription in June to August 2010 were selected, the prescriptions covered hospital representative subjects, the application of impatient antimicrobial drugs was described according to "Clinical Guide to Chinese Pharmacopoeia", "New...

Author(s): Yong Zhang and Bin Guo