Abstract

The aim of the study is to evaluate the anticancer potential of BS. Cytotoxicity assays was carried out to test the activity of BS against mouse model cancer and to test the activity of BS-contained serum against SGC; the human gastric cancer cell. Cytotoxicity assays showed that BS has a wide range of antitumor spectrum. Activity evaluation toward a set of BS-contained-serum that was derived from rat, at different time-intervals, respectively, indicates that when BS existed within rat body, as time was going on, its anticancer activity fluctuated dramatically, with two activity peak that was isolated by 2 to 3 h. It was concluded the BS’ potential as anticancer drug is promising.

Key words: Antibiotic, Bacillus subtilis (BS), in vivo, in vitro, anticancer.