African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

The effect of TGF-β1 on the Bax in rats with hypoxic brain damage after surgical treatment of gliomatosis cerebri (HBD/GC)

XianZhen Chen, ZhaoLi Shen, Fei Xue, Rui Shen and Jia Yin*
Department of Neurosurgery, Shanghai Tenth People’s Hospital,Tongji University School of Medcine, Shanghai 200072, P.R. China.
Email: [email protected]

  •  Accepted: 26 March 2012
  •  Published: 15 August 2012

Abstract

The effect of transforming growth factor beta 1 (TGF-β1) on Bax in rats with hypoxic brain damage after surgical treatment of gliomatosis cerebri (HBD/GC) were investigated. The SD rats were randomly divided into three groups: Sham control group, HBD/GC model group, HBD/GC + TGF-β1 injection treatment (E) group. The SD rats were treated in hypoxic environment after a surgical treatment of gliomatosis cerebri to establishe HBD/GC models. The expressions relative rate of Bax in CA1 region of hippocampus were detected by Reverse transcription-Polymerase chain reaction (RT-PCR) and Immunohistochemistry (ICH). After 24 h of operation, there was a significant decrease in Bax expression in E groups, while an increase in HBD/GC model group. TGF-β1 could comparatively increase the Bax mRNA and protein expressions in the hippocampal CA1 region of HBD/GC rats. These results suggested that TGF-β1 might develop its improvement by increasing Bax mRNA and protein expression in the CA1 region of hippocampal of HBD/GC rats.

 

Key words: Transforming growth factor beta 1, HBD/GC, Bax.

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