The effect of transforming growth factor beta 1 (TGF-β1) on Bax in rats with hypoxic brain damage after surgical treatment of gliomatosis cerebri (HBD/GC) were investigated. The SD rats were randomly divided into three groups: Sham control group, HBD/GC model group, HBD/GC + TGF-β1 injection treatment (E) group. The SD rats were treated in hypoxic environment after a surgical treatment of gliomatosis cerebri to establishe HBD/GC models. The expressions relative rate of Bax in CA1 region of hippocampus were detected by Reverse transcription-Polymerase chain reaction (RT-PCR) and Immunohistochemistry (ICH). After 24 h of operation, there was a significant decrease in Bax expression in E groups, while an increase in HBD/GC model group. TGF-β1 could comparatively increase the Bax mRNA and protein expressions in the hippocampal CA1 region of HBD/GC rats. These results suggested that TGF-β1 might develop its improvement by increasing Bax mRNA and protein expression in the CA1 region of hippocampal of HBD/GC rats.
Key words: Transforming growth factor beta 1, HBD/GC, Bax.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0