African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2157

Table of Content: 15 August, 2012; 6(30)

August 2012

Antioxidant and hepatoprotective effects of Oxalis corniculata against carbon tetrachloride (CCl4) induced injuries in rat

Many human diseases are caused due to oxidative stress involving excessive production of free radicals that can be ameliorated by the antioxidant activities of plant extracts. Present study was designed to characterize the chemical composition of Oxalis corniculata methanol extract (OCME) and its various fractions; O. corniculata n-hexane (OCHE), O. corniculataethyl acetate (OCEE), O....

Author(s): Muhammad Rashid Khan, Afifa Marium, Maria Shabbir, Naima Saeed and Jasia Bokhari

August 2012

Efficacy and safety of flurbiprofen axetil on preemptive analgesia for Chinese surgical patients: A meta-analysis

This study was performed to evaluate the efficacy and safety of flurbiprofen axetil (FA) on preemptive analgesia for Chinese surgical patients. Medicinal databases and review articles were screened with prespecified criteria for randomized controlled trials that reported the effects of adverse reactions to FA and other analgesics for preemptive analgesia. The qualities of included studies were critically evaluated. A...

Author(s): Huifen Li, Chunyan Zhang and Jintai Jia

August 2012

The effect of TGF-β1 on the Bax in rats with hypoxic brain damage after surgical treatment of gliomatosis cerebri (HBD/GC)

The effect of transforming growth factor beta 1 (TGF-β1) on Bax in rats with hypoxic brain damage after surgical treatment of gliomatosis cerebri (HBD/GC) were investigated. The SD rats were randomly divided into three groups: Sham control group, HBD/GC model group, HBD/GC + TGF-β1 injection treatment (E) group. The SD rats were treated in hypoxic environment after a surgical treatment of gliomatosis...

Author(s): XianZhen Chen, ZhaoLi Shen, Fei Xue, Rui Shen and Jia Yin

August 2012

The role of intralesional Pingyangmycin in the treatment of nasal polyp in aged population

This study is to investigate the effect of intralesional Pingyangmycin injection in nasal polyp. 82 patients with nasal polyp were treated with intralesional Pingyangmycin injection from September 2001 to September 2006. After a minimum follow-up of 2 years, 67 patients (81.7%) developed 76 to 100% regression in their lesions; 17 patients (18.3%) had 51 to 75% regression in their lesions. No changes in renal function or...

Author(s): Zhenghui Wang, Xianghong Zhang, Baoshu Li, Fang Quan and Miaoli Yang

August 2012

Ephrin B3 (EphB3) receptors expressed in spinal tissue of rats with spinal cord injury

Ephrin (Eph) receptors are the largest family of receptor tyrosine kinases (RTKs) and their membrane bound ligands, The Eph plays an important role in formation of spines with normal morpholog and synaptic plasticity. However, the Eph receptors expression in spinal tissue with spinal cord injury (SCI) was unclear to have little regarding molecular studies; thus, the present study aims to...

Author(s): Xiaodong Zhi, Mingyan Dong, Desui Yu, Yansong Wang, Da Huang and Gang Lv

August 2012

Service development in community pharmacies in Taiwan

Facing changes in the medical environment, community pharmacies are seeking new strategies and developing new services in order to survive. In this two-phase study, we explored certain aspects of service development in community pharmacies. The first phase involved collection of qualitative data through interviews. In the second phase, a quantitative study was designed on the basis of the results of interviews conducted...

Author(s): Yafang Tsai, , Chien-Ying Lee, , Shih-Wang Wu and Shwn-Huey Shieh

August 2012

Authentication of herbal drug Senna (Cassia angustifolia Vahl.): A village pharmacy for Indo-Pak Subcontinent

The present study deals with the taxonomic and pharmacognostic authentication of the herbal medicine Senna (Cassia angustifolia Vahl.). This plant of considerable pharmaceutical importance, has been recommended for constipation, piles, epilepsy, respiratory diseases, skin infections, migraine and heart diseases. No studies are available on the micro, Scanning Electron Microscopy (SEM), pharmacognostic and taxonomic...

Author(s): Shazia Sultana, Mushtaq Ahmad, Muhammad Zafar, Mir Ajab Khan and Muhammad Arshad

August 2012

Some in vitro and pharmacodynamic evaluation of indomethacin solid lipid microparticles

The purpose of this study was to investigate some in vitro and pharmacodynamic properties of indomethacin-loaded solid lipid microparticles (SLMs). A blend of homolipid from Caprahircus and Phospholipon® 90G comprised of the lipid matrix. The SLMs were prepared by the hot homogenisation technique. The effects of Carbosil® and sodium chloride on the release profile and particle...

Author(s): N. C. Obitte, S. A. Chime, A. A. Magaret, A. A. Attama, I. V. Onyishi and S. A. Brown

August 2012

Combination therapy with simvastatin and xuezhikang improves the lipid-lowering efficacy in hyperlipidemic rats

The objective of the present study was to investigate the effects of combination therapy with simvastatin and xuezhikang on the lipid-lowering efficacy and liver functions in hyperlipidemic rats. Forty (40) hyperlipidemic rats induced by feeding with high-fat diet for 6 weeks were randomly divided into four groups (n = 10), and treated with saline (10 ml/kg/d), simvastatin (12 mg/kg/d), xuezhikang (300 mg/kg/d) and...

Author(s): Yang Lin, Ming Cai, Yanru Lin and Hong Teng

August 2012

Ab initio studies of single-wall carbon nanotube for drug delivery of (N-acetyl-L-cysteinato-O, S) diphenyl tin (IV) anticancer drug

Carbon nanotubes (CNT) have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules. CNT can be attached to drugs, and used to deliver their cargos to cells and organs. In this work, the interaction behavior of the anticancer drug Sn(C6H5)2(N-acetyl-L-cysteinate) that is called (N-acetyl-Lcysteinato-O,S) diphenyl tin (IV) when binding single-walled carbon nanotubes was...

Author(s): Amir Sobhanmanesh, Majid Monajjemi, Karim Zare and Golnaz Shams