Six novel piperidine derivatives, compounds 5 to 10, have been synthesized and their antimicrobial and anti-oxidant activities evaluated using agar disc diffusion (antimicrobial) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity (antioxidant). Compound 9 revealed the least antibacterial activity. Compound 6 exhibited the strongest inhibitory activity and the best minimum inhibitory concentration (MIC) results against the seven bacteria tested in comparison to the other piperidine derivatives (5, 7, 8, 9, and 10). All six piperidine compounds displayed no activity against fungal species, Fusarium verticilliodes, Candida utilus and Penicillium digitatium. Compounds 7 and 8 revealed no activity against all seven fungi tested. Compounds 5, 6, 9, and 10 revealed varying degree of inhibition against Aspergillus niger, Aspergillus flavus, Saccharomyces cerevisiae and Candida albicans. Compound 8 demonstrated the highest scavenging capacity of 78% at 1000 µg/ml and compound 6 demonstrated the least percentage of scavenging potential of 49% at 1000 µg/ml. All piperidine derivatives tested, revealed antioxidant potentials greater than 49% at 1 mg/ml as compared to the control Rutin, which displayed 97% scavenging capacity at the same concentration. All piperidine derivatives revealed varying degree of antimicrobial and antioxidant activities.
Key words: 1,2,5,6-Tetrahydropyridine (THP), piperidine derivatives, antibacterial, antifungal, antioxidant.
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