African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2250

Full Length Research Paper

Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn. in alloxan-induced diabetic rabbits

Alamgeer1*, Muhammad Naveed Mushtaq1, Sajid Bashir1, Muhammad Rashid1, Muhammad Nasir Hayat Malik1, Shazia Akram Ghumman1, Hafiz Muhammad Irfan1, Muhammad Akram1, Abdul Qayyum Khan1 and Haroon-Ur-Rashid2
1Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan. 2Department of Radiotherapy and Nuclear Medicine, Sargodha Medical College, University of Sargodha, Pakistan.
Email: [email protected]

  •  Accepted: 06 August 2012
  •  Published: 31 October 2012

Abstract

This study was designed to evaluate the effect of aqueous extract of Thymus serpyllum Linn. on blood glucose level, body weight, and some hematological parameters of alloxan induced diabetic rabbits for a period of one month. It was found that the aqueous extract significantly (P < 0.01) reduced the blood glucose level in diabetic rabbits. This decrease in blood glucose level was comparable to the effect of standard drugs glibenclamide and acarbose. The aqueous extract also maintained the body weight of alloxanized rabbits. Significant increase was observed in erythrocyte sedimentation rate (ESR) and monocytes level in the diabetic treated rabbits as compared to the diabetic control non-treated group. ESR and monocytes level were significantly increased, whereas red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), neutrophils, hemoglobin (Hb) level, and platelets were significantly decreased in diabetic control non-treated rabbits, while these parameters in aqueous extract treated diabetic rabbits were comparable with normal control group. In conclusion, oral administration of aqueous extract of T. serpyllum produced hypoglycemic effects in alloxan-diabetic-rabbits, protected weight loss, and ameliorated diabetic-induced hematological disturbances in rabbits.    

 

Key words: Diabetes, hematological parameters, hypoglycemia, Thymus serpyllum Linn