African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 29 October, 2012; 6(40)

October 2012

Anti-inflammatory effect of Papenfussiella kuromo in lipopolysaccharide or peptidoglycan-induced macrophage cells

Marine bioresources are known to be attractive as they sometimes contain new compounds showing several kinds of different bioactivities which are not possible in land plants. Brown algae, Papenfussiella kuromo is widely distributed in Korea and Japan. However, no studies have been conducted to evaluate the anti-inflammatory activities of the extract of P. kuromo. We studied its anti-inflammatory effect in...

Author(s): Ok-Hwa Kang, Sung-Bae Kim, Dae-Ki Joung, Su-Hyun Mun, Yun-Soo Seo, Ma-Ryong Kim, Dong-Won Shin, Han-Gil Choi, Kee-Tae Kweon and Dong-Yeul Kwon

October 2012

The effect of salidroside on inflammatory factors in rats with hemisection-induced spinal cord injury

The effect of salidroside on inflammatory factors in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague-Dawley (SD) rats were divided into six groups: Sham control group, SCI model group, the methylprednisolone sodium succinate (MPSS) treatment group, the salidroside-low dosage treatment group, the salidroside-moderate dosage treatment group and the salidroside-high dosage treatment group....

Author(s): Jun Hu, Cuiping Zhong and Xingyan Liu

October 2012

Chemical assessment of wild Paris rhizome from Southwest China

Chonglou is a well known traditional Chinese medicine for anti-cancer and traumatic injuries. The major sources of Chonglou are from genus Paris. The present investigation aimed to determine contents of active steroidal saponins in Paris plants collected from different locations of Southwest China. The results showed that polyphyllin I and polyphyllin VII could be detected in almost all samples. However,...

Author(s): Jinyu Zhang, Tao Shen, Yuanzhong Wang, Ji Zhang, Yundong Shi and Hang Jin

October 2012

Antimicrobial activity of Melampyrum cristatum, Melampyrum bihariense and Melampyrum arvense tinctures

The infections with bacteria and fungi resistant to existing chemotherapeutic drug have become a serious problem in the whole world, which leads to the continuous need to develop new antimicrobial agents. The plants extracts may represent future solutions against these pathogens. The purpose of this study was to determine the antibacterial and antifungal activity of Melampyrum cristatum, Melampyrum...

Author(s): Melania F. Munteanu, Ramona Gligor, Ioan Crîsnic, Carmen A. Costache and Ioana A. Colosi

October 2012

Methylation in non-coding sequences may be related to the tolerance of common carp to cadmium

In order to understand the molecular mechanism underlying the tolerance of common carp to cadmium (Cd), we exposed three-month old common carp (Cyprinus carpio var. Jian) to different concentrations of Cd2+ (0.005, 0.05, 0. 5 and 5 mg/L) for 2 days. Results showed that no individual died during the exposure. Furthermore, we used 10 random amplified polymorphic DNA (RAPD) primers to detect the difference in the...

Author(s): Zheming Cao, and Weidong Ding

October 2012

MG132 reduces the pro-inflammatory effect of cyclooxygenase 2 (COX-2) on glomerular mesangial cells

Cyclooxygenase 2 (COX-2) over expression is involved in the proliferation of mesangial cells in the pathogenesis of glomerulonephritis, and nuclear factor kappa B (NF-κB) signaling participates in the induction of COX-2 gene expression in these cells. This study explores the effect of MG132, a NF-κB proteasome inhibitor, on the pro-inflammatory effect of glomerular COX-2 gene overexpression. A...

Author(s): Hai-ying Liu, Tong Wu, Fang-fang Huang and Tao Wu

October 2012

Expression of interleukin 17 and IgE, and its significance in patients with bronchial asthma

To investigate the expression and its significance of interleutin-17 (IL-17) and immunoglobulin E (IgE) in patients with bronchial asthma, sixty adult patients with bronchial asthma and 30 healthy human control were sequentially enrolled in this study. The production of IL-17 was measured by enzyme-linked immunosorbent assay (ELISA) and fluorescent quantitative polymerase chain reaction (qPCR), respectively. The...

Author(s): Honghua Lu, Li Liu, Huanji Cheng, Yunfeng Zhang and Shucheng Hua

October 2012

Clinical management of lipid profile, renal and liver function versus HbA1c profile in diabetes affected patients of Vellore, Tamil Nadu, India

The aim of this study is to examine clinical management of lipid profile, renal and liver function versus HbA1c value correlation in diabetic population of Vellore district in South India. A total of 1300 cases from three different diabetic clinics in Vellore were taken for the study. 25% of populations were selected as control.Parameters such as age, sex, fasting blood glucose, postprandial blood glucose, lipid...

Author(s): A. Arivarasan, Gaurav Rana, Archita Sharma, Manish Kumar, Karishma Jhang, Arundhati Chakraborty, Pravir Kumar, and Rashmi K Ambasta,

October 2012

Antinociceptive and neuropharmacological activities of ethanolic extract of the fruits of Ficus hispida Linn.

The crude ethanolic extract of the fruits of Ficus hispida Linn. (Family: Moraceae) growing in southeast part of Bangladesh has been evaluated for its possible antinociceptive and neuropharmacological properties. The ethanolic extract of the fruits of F. hispida exhibited statistically significant (p < 0.001) writhing inhibition in acetic acid-induced writhing model in white albino...

Author(s): Sariful Islam Howlader, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed and Hemayet Hossain

October 2012

Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn. in alloxan-induced diabetic rabbits

This study was designed to evaluate the effect of aqueous extract of Thymus serpyllum Linn. on blood glucose level, body weight, and some hematological parameters of alloxan induced diabetic rabbits for a period of one month. It was found that the aqueous extract significantly (P < 0.01) reduced the blood glucose level in diabetic rabbits. This decrease in blood glucose level was comparable to the effect of...

Author(s): Alamgeer, Muhammad Naveed Mushtaq, Sajid Bashir, Muhammad Rashid, Muhammad Nasir Hayat Malik, Shazia Akram Ghumman, Hafiz Muhammad Irfan, Muhammad Akram, Abdul Qayyum Khan and Haroon-Ur-Rashid