African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Optimization for ultrasonic-assisted extraction of salidroside from Ligustrum lucidum by central composite design-response surface methodology

Yuandong Hu1,2*, Yan Wu2 and Hong Song2
1Department of Environmental Science, East China Normal University, Shanghai 200062, China. 2Northeast Forestry University, Harbin 150040, China.
Email: [email protected]

  •  Accepted: 04 June 2012
  •  Published: 29 July 2012

Abstract

As a new extraction method, ultrasonic-assisted extraction (UAE), whose procedure has higher extraction yield, lower extracting temperature and less power consumption, was explored to extract salidroside from Ligustrum lucidum firstly. The content of salidroside was determined by reverse phase-high performance liquid chromatography (RP-HPLC). The UAE process of salidroside from L. lucidum was optimized by using central composite design-response surface methodology (CCD-RSM). The results showed that the optimal extraction conditions were ethanol concentration of 74.14%, liquid-solid ratio of 30.31, extracting time of 68.14 min and the extraction efficiency of salidroside was 4.68 mg;g-1. The results indicated that the UAE would be a novel method for extraction of salidroside from L. lucidum.

 

Key words: Ultrasonic-Assisted Extraction (UAE), central composite design-response surface methodology, Ligustrum lucidum, reverse phase-high performance liquid chromatography (RP-HPLC).

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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