July 2012
Preparation and evaluation of a sustained-release suspension containing theophylline microcapsules
A great effort has been devoted to the preparation of sustained-release formulations of theophylline to prevent large fluctuations of serum concentration and increasing the therapeutic efficacy followed by patient compliance. In the present study, microcapsules of theophylline with ethyl cellulose (EC) were prepared by emulsion-solvent evaporation method in different polymer to drug ratios. Size, morphology, drug...
July 2012
Taurine inhibits myocardial fibrosis via PKCα and iNOS signaling pathways
Although, taurine has demonstrated the important role in inhibiting proliferation of myofibroblasts (myoFb) and reversing cardiac remodeling, the underlying mechanisms remains largely unknown. Therefore, the present study is designed to shed light on this issue through exploring the signal pathways. The proliferation and cycle distribution of cultured myoFb were measured by MTT and flow cytometry assay, nitric oxide...
July 2012
Effect of oxytocin (OT) and OT plus human chorionic gonadotropin (hCG), in cycles induced by letrozole or clomiphene citrate (CC)
The aim of this study is to compare the early clinical outcomes in cycles induced by letrozole and clomiphene citrate (CC) combined with oxytocin (OT) or OT + human chorionic gonadotropin (hCG) in anovulatory patients. We conducted a randomized controlled prospective clinical study in the clinics of Tabriz University of Medical Sciences from October, 2007 to September, 2009. One hundred and seventy-seven infertile women...
July 2012
Mouse ovarian-related gene expression profiles change with intraperitoneal injection of cisplatin
Cisplatin (DDP), an important anti-cancer drug, can affect normal ovarian function. However, the underlying pathophysiological mechanism is unclear. Thus, to analyze the mechanism of its ovary function, modulation effect was evaluated by noting the effect of its injection on ovary related gene expression in mice. Total mRNA of mice ovary tissue after administration of cisplatin and the normal control group was extracted...
July 2012
Preparation and evaluation of sustained release pellets of Tramadol
Preparation of sustained release dosage forms is one of the main objectives in drug formulation. Tramadol is a centrally acting synthetic opioid analgesic used in treating severe pain. In this study, Tramadol sustained release pellets were prepared using two methods and the effect of type, ratio of polymers and plasticizers on drug loading and drug release profile was studied. From the results...
July 2012
Efficacy of different medicines used for the treatment of osteoporosis by using dual energy x-ray absorptiometry
Osteoporosis, a skeletal disease and common condition affecting one in three women and one in twelve men is a major health burden worldwide and in our population as well. A total of 180 patients including 30 in control group, 126 osteoporotics and 54 osteopenics, were diagnosed and analyzed with the help of bone mineral density (BMD) by dual energy x-ray absorptiometry (DEXA) and treated in different groups with...
July 2012
Effect of perioperative administration of parecoxib on post-tonsillectomy pain in adults
Post-tonsillectomy pain is one of the most difficult pain states to manage in otolaryngology. In this study, we investigated the analgesic effect of parecoxib in adults undergoing tonsillectomy. Eighty-eight patients that underwent tonsillectomy were randomly allocated to two groups to receive either intravenous 80 mg 24 h-1 parecoxib (group P) or saline as control (group C) at two medical center of university....
July 2012
Optimization for ultrasonic-assisted extraction of salidroside from Ligustrum lucidum by central composite design-response surface methodology
As a new extraction method, ultrasonic-assisted extraction (UAE), whose procedure has higher extraction yield, lower extracting temperature and less power consumption, was explored to extract salidroside from Ligustrum lucidum firstly. The content of salidroside was determined by reverse phase-high performance liquid chromatography (RP-HPLC). The UAE process of salidroside from L. lucidum was...
July 2012
Comparison of the volatile compounds of crude and processed Atractylodis rhizome analyzed by GC-MS
Atractylodis rhizome is an important Chinese medicinal herb which is used extensively in the practice of Traditional Chinese medicine (TCM). Processing is a common practice and usually occurs before Atractylodis rhizome is prescribed. However, how to evaluate the quality of processed Atractylodis rhizome has not been reported. In order to evaluate the composition of essential oil induced by the processing, the essential...
July 2012
Descriptive study for look-alike and sound-alike medicines based on local language peculiarities
The existence of confusing drug names was considered one of the leading causes of medication errors. The aim of the study was to summarize the potential sources for errors associated with look-alike and sound-alike (LASA) medicines, to provide overview of the most common patterns and offer recommendations of safety strategies to help mitigate the problem. A standardized questionnaire was conducted for a...
July 2012
Characterization and the expression profile of 4-coumarate: CoA ligase (Ii4CL) from hairy roots of Isatis indigotica
The enzyme 4-coumarate: CoA ligase (4CL) activates cinnamic acid and its hydroxylated derivatives by forming the corresponding CoA thioesters. These serve as substrates for biosynthesis of phenylpropanoid-derived secondary metabolites for the medicinal herbal Isatis indigotica. To investigate the function of 4CL gene, we have characterized this gene namedIi4CL with GenBank Accession No. GQ872418. The...
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