African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Evaluation of hypoglycaemic and antihyperglycaemic activity of methanolic wholeplant extract of Schwenckia americana (Solanacae) in normal and alloxan-induced diabetic rats

Bello, S. O.1, Chika, A.1*, Jimoh, A. O.1, Abubakar, K.2 and Adebisi, I.2
1Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria. 2Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Email: [email protected]

  •  Accepted: 14 October 2013
  •  Published: 22 October 2013

Abstract

Powdered whole plant of Schwenckia americana (family Solanacae) is used traditionally (in combination with other herbs) for treating diabetes mellitus in Northern Nigeria. Therefore, in the current study, the traditional claim was evaluated by testing the effects of methanolic extract of S. americana whole plant on blood glucose in normal, alloxan-induced sub-diabetic and alloxan-induced diabetic rats. The median lethal dose after oral administration of the extract in rats was found to be above 5,000 mg per kilogram of body weight. The extract significantly lowered blood glucose in normal and alloxan-induced subdiabetic rats but not in alloxan-induced diabetic rats. It is concluded that S. americana may reduce blood sugar in type 2 diabetes, thus vindicating the traditional claim of its antidiabetic property.

Key words: Schwenckia americana, blood sugar, rats.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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